Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division dynamin-related GTPase (DRP1) and mitochondrial division dynamin I (Dnm1). Division and mitochondrial fusion play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
Tanaka, A., and Youle, R.J. , A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol. Cell. 29, 409-410, (2008); Cassidy-Stone, A., et al., Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell 14, 193-204, (2008)
Soluble in DMSO (>20 mg/ml).
Store at -20° C
229.59° C (Predicted)
~522.46° C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.73 (Predicted)
Dnm1 GTPase: IC50 = 1 - 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Mdivi-1 excellent productExcellent product and very usefull to study mitochondrial dynamics and apoptosis. I recommend to read Alaimo et al. 2014. Plos One. http://dx.doi.org/10.1371/journal.pone.0091848
Date published: 2017-01-26
Rated 5 out of
LiuLiu, JM. et al. (PubMed 25818100) investigated the beneficial effects of Mdivi-1, an inhibitor of mitochondrial division DRP1 and Dynamin I, against spinal cord ischemia-reperfusion (SCIR) injury and its associated mechanisms. They found that Mdivi-1 significantly attenuated glutamate induced neuronal injury and apoptosis in spinal cord neurons. The in vivo experiments showed that Mdivi-1 treatment mitigated SCIR injury induced spinal cord edema and neurological dysfunction with no organ-related toxicity in rats. -SCBT Publication Review
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