Mdivi-1

Mdivi-1 (CAS 338967-87-6)

Mdivi-1 | CAS 338967-87-6 is rated 5.0 out of 5 by 2.
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Synonym: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Application: An inhibitor of mitochondrial division DRP1 and Dynamin I
CAS Number: 338967-87-6
Purity: ≥97%
Molecular Weight: 353.22
Molecular Formula: C15H10Cl2N2O2S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division dynamin-related GTPase (DRP1) and mitochondrial division dynamin I (Dnm1). Division and mitochondrial fusion play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.


References

Tanaka, A., and Youle, R.J. , A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol. Cell. 29, 409-410, (2008); Cassidy-Stone, A., et al., Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell 14, 193-204, (2008)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml).
Storage :
Store at -20° C
Melting Point :
229.59° C (Predicted)
Boiling Point :
~522.46° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
IC50 :
Dnm1 GTPase: IC50 = 1 - 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
3825829
MDL Number :
MFCD00974506
SMILES :
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl

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Certificate of Analysis

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Mdivi-1  Product Citations

See how others have used Mdivi-1. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26163003  Gorojod, RM. et al. 2015. Free Radic. Biol. Med. 87: 237-51.

PMID: # 25126734  Zhang, X. et al. 2014. Autophagy. 10: 1801-13.

PMID: # 24632637  Alaimo, A. et al. 2014. PloS one. 9: e91848.

PMID: # 23800795  Zhang, X. et al. 2013. Autophagy. 9: 1321-33.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Mdivi-1 excellent product Excellent product and very usefull to study mitochondrial dynamics and apoptosis. I recommend to read Alaimo et al. 2014. Plos One. http://dx.doi.org/10.1371/journal.pone.0091848
Date published: 2017-01-26
Rated 5 out of 5 by from Liu Liu, JM. et al. (PubMed 25818100) investigated the beneficial effects of Mdivi-1, an inhibitor of mitochondrial division DRP1 and Dynamin I, against spinal cord ischemia-reperfusion (SCIR) injury and its associated mechanisms. They found that Mdivi-1 significantly attenuated glutamate induced neuronal injury and apoptosis in spinal cord neurons. The in vivo experiments showed that Mdivi-1 treatment mitigated SCIR injury induced spinal cord edema and neurological dysfunction with no organ-related toxicity in rats. -SCBT Publication Review
Date published: 2015-05-10
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