MDA 19A selective human peripheral cannabinoid CB2 receptor agonist

MDA 19 (CAS 1048973-47-2)

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Application: A selective human peripheral cannabinoid CB2 receptor agonist
CAS Number: 1048973-47-2
Molecular Weight: 349.4
Molecular Formula: C21H23N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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MDA 19 is a selective agonist of the human peripheral cannabinoid CB2 receptor, with an EC50 for activation (63.4 nM) that is 14-fold lower than that for CB1 activation (EC50 = 867 nM). Surprisingly, it acts as an inverse agonist at the rat CB2 receptor in cell-based functional assays.


References

1. Diaz, P., et al. 2008. J. Med. Chem. 51: 4932-4947. PMID: 18666769
2. Xu, J.J., et al. 2010. Anesth. Analg. 111: 99-109. PMID: 20522703

Physical State :
Solid
Solubility :
Soluble in ethanol (~3 mg/ml), DMSO (~10 mg/ml), and DMF (~20 mg/ml).
Storage :
Store at -20° C
IC50 :
CB2: EC5050 = 63.4 nM (human); CB1: EC5050 = 867 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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