MCPyV large T-antigen Antibody (CM2B4) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against large T/57kT exon 2 peptides of Merkel cell polyomavirus
recommended for detection of Merkel Cell Polyomavirus by WB, IP, IF and IHC(P)
available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact us to receive a FREE 10 µg sample of MCPyV large T-antigen (CM2B4): sc-136172.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Merkel cells are round neuroendocrine cells found in skin that have synaptic contacts with somatosensory afferents. Responsible for touch and pressure sensation, Merkel cells can turn malignant and form a rare but aggressive form of skin cancer known as Merkel cell carcinoma (MCC). Approximately 80% of MCC are caused by a newly-described polyomavirus called Merkel cell polyomavirus, also known as MCPyV or MCV, that expresses a large T antigen in tumor cells. Full-length MCPyV large T antigen is a 125 kDa nuclear protein but MCPyV T antigens obtained from tumors have natural truncating mutations resulting in variably-sized, smaller proteins. MCPyV large T-antigen (CM2B4) was raised against a peptide in exon 2 of the T antigen locus and is highly specific for MCPyV large T and 57kT isoforms but will not detect MCPyV small T antigen. While human MCPyV infection is widespread, MCPyV large T antigen is a specific marker for Merkel cell tumors.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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