MCI-186, also known as 3-methyl-1-phenyl-2-pyrazolin-5-one, is a free radical scavenger that has been shown to contain protective properties towards murine brain ischemia. In vitro this compound has been reported to decrease cell death in murine models. Mechanistic studies suggest that MCI-186 enhances neuronal growth factor (NGF) protein levels which are essential for neuronal growth and survival. Furthermore, the enhancement of NGF expression in astrocytes has been thought to be done via the c-Jun N-terminal Kinase (JNK) pathway.
1. Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281: 921-927. PMID: 9152402 2. Zhou, F., et al. 2009. Brain Inj. 23: 353-357. PMID: 19330597 3. Lee, B.J., et al. 2010. Brain Res. 1307: 22-27. PMID: 19840779 4. Yoshida, H., et al. 2010. Neurosci. Res. 66: 284-289. PMID: 19954754
Soluble in water (3.3 g/L) at 20° C, DMSO (~30 mg/ml), methanol, ethanol (~15 mg/ml), DMF (~50 mg/ml), and a 1:9 solution of DMF:PBS(pH7.2) (~0.1 mg/ml).
Store at room temperature
126-128° C (lit.)
287° C at 265 mmHg
1.12 g/cm3 at 20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
See how others have used MCI-186. Click on the entry to view the PubMed entry
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Takahashi et alTakahashi et al. (PubMed ID 14666020) found that MCI-186 prevented spinal chord damage after ischemia by decreasing nitric oxide synthase in neurons and increasing endothelial NO synthase.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.