MastoparanA G-protein activator

Mastoparan (CAS 72093-21-1)

Mastoparan | CAS 72093-21-1 is rated 5.0 out of 5 by 1.
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Application: A G-protein activator
CAS Number: 72093-21-1
Molecular Weight: 1478.93
Molecular Formula: C70H131N19O15
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mastoparan (Vespula lewisii) has been shown to cause an increase in the production of Arachidonic Acid (sc-200770) catalyzed by PLA2 from porcine pancreas and bee venom. This compound also displays toxicity by regulating G proteins via mimicking of G-protein-coupled receptors. Additionally, Mastoparan has been reported as a stimulator of insulin release by pancreatic islets, which acts through GTP-binding proteins and PLA2. In other experiments, this agent has demonstrated the ability to cause exocytosis of rat peritoneal mast cells and also stimulate the accumulation of inositol phosphates in hepatocytes. Additionally, Mastoparan has been noted to act as a mitogen in Swiss 3T3 cells and stimulate pertussis toxin-sensitive Arachidonate release without phosphoinositide breakdown. Mastoparan (Vespula lewisii) is an inhibitor of CaM. Mastoparan (Vespula lewisii) is an activator of Heterotrimeric G Protein and PLA2.


References

1. Argiolas, A. and Pisano, J.J. 1983. J. Biol. Chem. 258: 13697-13702. PMID: 6643447
2. Higashijima, T., et al. 1988. J. Biol. Chem. 263: 6491-6494. PMID: 3129426
3. Yokokawa, N., et al. 1989. Biochem. Biophys. Res. Commun. 158: 712-716. PMID: 2493246
4. Mousli, M., et al. 1989. J. Pharmacol. Exp. Ther. 250: 329-335. PMID: 2473189
5. Higashijima, T., et al. 1990. J. Biol. Chem. 265: 14176-14186. PMID: 2117607
6. Gil, J., et al. 1991. J. Cell Biol. 113: 943-950. PMID: 1709171

Physical State :
Solid
Derived From :
Synthetic. Originally isolated from wasp venom (Vespula lewisii)
Solubility :
Soluble in water (2.6 mg/ml), and 100% ethanol.
Storage :
Store at -20° C
Refractive Index :
n20D 1.53
IC50 :
Na+,K+-ATPase: IC50 = 7.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5464497
MDL Number :
MFCD00076865
Beilstein Registry :
5491949
SMILES :
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N)N

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Certificate of Analysis

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Rated 5 out of 5 by from Mastoparan was reported in many articles Mastoparan was reported in many articles as a wasp peptide with activity against resistant Acinetobacter baumannii. -SCBT Publication Review
Date published: 2015-03-12
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