Maslinic Acid A pentacyclic triterpene with antiproliferative properties

Maslinic Acid (CAS 4373-41-5)

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Application: A pentacyclic triterpene with antiproliferative properties
CAS Number: 4373-41-5
Molecular Weight: 472.7
Molecular Formula: C30H48O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Maslinic Acid is a pentacyclic triterpene with antioxidant and anti-inflammatory properties. Studies indicate that Maslinic Acid blocks the generation of nitric oxide, and inhibits the secretion of IL-6 and TNF-α induced by lipopolysaccharides. Maslinic Acid is described to have antiproliferative and anti-HIV properties. In addition, Maslinic Acid is suggested to have a neuroprotective affect by amplifying the expression of astrocytic glutamate transporters and regulating the extracellular glutamate concentration. Research also indicates that Maslinic Acid inhibits the NF-Kβ signaling pathway and increases the affect of TNF-α induced apoptosis.


References

1. Márquez Martín, A., et al. 2006. Free Radic. Res. 40: 295-302. PMID: 16484046
2. He, X. and Liu, R.H. 2007. J. Agric. Food Chem. 55: 4366-4370. PMID: 17488026
3. Parra, A., et al. 2009. Bioorg. Med. Chem. 17: 1139-1145. PMID: 19135380
4. Li, C., et al. 2010. Mol. Cancer. 9: 73. PMID: 20367887
5. Qian, Y., et al. 2011. Eur. J. Pharmacol. 651: 59-65. PMID: 21118675

Physical State :
Solid
Solubility :
Soluble in water (0.3 mg/ml at 25° C), ethanol (~0.5 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), and 1: 2 solution of ethanol : PBS (pH 7.2) (~0.3 mg/ml).
Storage :
Store at -20° C
Melting Point :
241.38° C (Predicted)
Boiling Point :
569.97° C at 760 mmHg (Predicted)
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
AKR1B10: IC50 = 0.63 µM (human); PTP1B: IC50 = 5.93 µM (human); CCRF-CEM: IC50 = 7 µM (human leukemia cells); CEM/ADR5000: IC50 = 9 µM (human leukemia cells); Caco-2 cancer cells: EC5050 = 15 µM
pK Values :
pKa: 4.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
73659
MDL Number :
MFCD00049293
SMILES :
C[C@@]12CC[C@@H]3[C@@]([C@H]1CC=C4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)(C[C@H]([C@@H](C3(C)C)O)O)C

Download SDS (MSDS)

Certificate of Analysis

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