Maprotiline Hydrochloride A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons

Maprotiline Hydrochloride (CAS 10347-81-6)

Maprotiline Hydrochloride | CAS 10347-81-6 is rated 5.0 out of 5 by 1.
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Synonym: Ludiomil; Psymion
Application: A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons
CAS Number: 10347-81-6
Purity: ≥98%
Molecular Weight: 313.87
Molecular Formula: C20H23N•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Maprotiline Hydrochloride is an inhibitor of norepinephrine reuptake. It acts primarily by potentiation of central adrenergic (AR) synapses by blocking reuptake of norepinephrine at nerve endings. Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.


References

1. Yamaguchi, M., et al. 1999. Anal. Biochem. 270: 296-302. PMID: 10334847
2. Mochizucki, D. 2004. Hum. Psychopharmacol. 19: S15-19. PMID: 15378668
3. Mayers, A.G., et al. 2005. Hum. Psychopharmacol. 20: 533-559. PMID: 16229049
4. Tang, T.S., et al. 2005. Proc. Natl. Acad. Sci. U.S.A. 102: 2602-2607. PMID: 15695335

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), and ethanol (10 mM).
Storage :
Store at room temperature
Melting Point :
230-232° C
Refractive Index :
n20D 1.60
IC50 :
PhoP regulon: IC50 = 53.52 µM (Salmonella typhi)
pK Values :
pKb: 10.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KJ4555000
PubChem CID :
71478
Merck Index :
14: 5748
MDL Number :
MFCD00079464
EC Number :
233-758-8
SMILES :
CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl

Download SDS (MSDS)

Certificate of Analysis

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Maprotiline Hydrochloride  Product Citations

See how others have used Maprotiline Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 15236632  Hsu, SS. et al. 2004. Clin. Exp. Pharmacol. Physiol. 31: 444-449.

PMID: # 7581917  Ishida, J. et al. 1995. J. Chromatogr. B, Biomed. Appl. 669: 390-396.

PMID: # 1852793  de Jonghe, F. et al. 1991. Pharmacopsychiatry. 24: 62-67.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Gurgel Gurgel, JA. et al. (PubMed 24402214) reported that Amitriptyline, Clomipramine, and Maprotiline attenuate the inflammatory response by inhibiting neutrophil migration and mast cell degranulation. -SCBT Publication Review
Date published: 2015-07-03
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