Maprotiline Hydrochloride is an inhibitor of norepinephrine reuptake. It acts primarily by potentiation of central adrenergic (AR) synapses by blocking reuptake of norepinephrine at nerve endings. Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.
1. Yamaguchi, M., et al. 1999. Anal. Biochem. 270: 296-302. PMID: 10334847 2. Mochizucki, D. 2004. Hum. Psychopharmacol. 19: S15-19. PMID: 15378668 3. Mayers, A.G., et al. 2005. Hum. Psychopharmacol. 20: 533-559. PMID: 16229049 4. Tang, T.S., et al. 2005. Proc. Natl. Acad. Sci. U.S.A. 102: 2602-2607. PMID: 15695335
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Soluble in water (50 mg/ml), and ethanol (10 mM).
Store at room temperature
PhoP regulon: IC50 = 53.52 µM (Salmonella typhi)
pKb: 10.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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See how others have used Maprotiline Hydrochloride. Click on the entry to view the PubMed entry
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GurgelGurgel, JA. et al. (PubMed 24402214) reported that Amitriptyline, Clomipramine, and Maprotiline attenuate the inflammatory response by inhibiting neutrophil migration and mast cell degranulation. -SCBT Publication Review
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