MAP kinase substrate (MBP) A peptide substrate for ERK 1 and ERK 2 MAP kinases

MAP kinase substrate (MBP)

MAP kinase substrate (MBP) is rated 5.0 out of 5 by 1.
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Synonym: MAP Kinase Substrate 2 (Myelin Basic Protein 90-98); APRTPGGRR; MBP MAPK Substrate
Application: A peptide substrate for ERK 1 and ERK 2 MAP kinases
Purity: ≥95% pure by HPLC
Molecular Weight: 967.1
* Refer to Certificate of Analysis for lot specific data (including water content).
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MAP kinase substrate (MBP) is a peptide substrate for ERK 1 and ERK 2 MAP kinases. Sequence contains amino acids 95-98 of myelin basic protein (MBP) including Thr 97 within the Pro-X-Ser/Thr-Pro MAP kinase substrate consensus sequence phosphorylation site.


References

1. Clark-Lewis, I., et al., 1991. Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. The Journal of biological chemistry. 266(23): 15180-4. PMID: 1907971
2. Daeipour, M., et al., 1993. Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10. Journal of immunology (Baltimore, Md. : 1950). 150(11): 4743-53. PMID: 8388418
3. Gerthoffer, W T., et al., 1996. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. The Journal of physiology. 495 ( Pt 3)(): 597-609. PMID: 8887769
4. Kameshita, I., et al., 1997. A new peptide conjugate as a highly specific substrate for MAP kinase. Journal of biochemistry. 122(1): 168-72. PMID: 9276684
5. Song, S., et al., 1998. Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(11): 4119-32. PMID: 9592092
6. Sommer, F., et al., 2002. MAP kinase 1/2 (Erk 1/2) and serine/threonine specific protein kinase Akt/PKB expression and activity in the human corpus cavernosum. International journal of impotence research. 14(4): 217-25. PMID: 12152110
7. Nam, Hui-Sun., et al., 2002. Determination of protein phosphorylation by extracellular signal-regulated kinase using capillary electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Journal of chromatography. A. 976(1-2): 79-85. PMID: 12462598
8. Lents, Nathan H., et al., 2002. Activation and phosphorylation on Thr-160 of nuclear-targeted CDK2 Is ERK dependent. Annals of the New York Academy of Sciences. 973(): 265-7. PMID: 12485874

Physical State :
Solid
Sequence :
H2N-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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MAP kinase substrate (MBP)  Product Citations

See how others have used MAP kinase substrate (MBP). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 16676348  Ko, JH. et al. 2006. J. Cell. Biochem. 99: 719-734.

PMID: # 15585853  Singh, R.A. et al. 2004. J. Immunology. 173: 7299-7307.

PMID: # 11923207  Di Agostino, S. et al. 2002. Development. 129(7): 1715-1727.

PMID: # 11891332  Minamino T, et al. 2002. Proc. Natl. Acad. Sci. USA. 99: 3866-3871.

PMID: # 10383890  1999. Carcinogenesis. 20: 1201-8.

PMID: # 10559244  Sette, C. et al. 1999. J. Biol. Chem. 274: 33571-33579.

PMID: # 9642252  1998. J. Biol. Chem. 273: 16905-12.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Starkey DE; et al Starkey DE; et al. (PubMed ID: 12711339) utilized MAP kinase substrate (MBP) to measure the phosphorylation of ERK. -SCBT Publication Review
Date published: 2015-03-14
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