Manzamine A A β-Carboline alkaloid with anti-inflammatory

Manzamine A (CAS 104196-68-1)

Manzamine A | CAS 104196-68-1 is rated 5.0 out of 5 by 1.
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Synonym: Keramamine A
Application: A β-Carboline alkaloid with anti-inflammatory
CAS Number: 104196-68-1
Purity: >98%
Molecular Weight: 548.76
Molecular Formula: C36H44N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Manzamine A is a β-carboline alkaloid isolated from the marine sponge Xestospongia ashmorica that acts as a GSK-3β inhibitor. The compound is reported to have activity against the gram-positive bacteria: Staphylococcus aureus and Bacillus subtilis. Malaria studies report Manzamine A to block the asexual erythrocytic stage of Plasmodium berghei. Furthermore, Manzamine A has been suggested to have anti-HIV, anti-inflammatory, and antifungal activity.


References

1. Edrada, R.A., et al. 1996. J. Nat. Prod. 59: 1056-1060. PMID: 8946747
2. Ang, K.K., et al. 2000. Antimicrob. Agents Chemother. 44: 1645-1649. PMID: 10817722
3. Ang, K.K., et al. 2001. Parasitol. Res. 87: 715-721. PMID: 11570556
4. Rao, K.V., et al. 2003. J. Nat. Prod. 66: 823-828. PMID: 12828469
5. Khalil, A., et al. 2003. Pharmazie. 58: 385-388. PMID: 12856999
6. Yousaf, M., et al. 2004. J. Med. Chem. 47: 3512-3517. PMID: 15214779
7. Hamann, M., et al. 2007. J. Nat. Prod. 70: 1397-1405. PMID: 17708655

Appearance :
Oil
Physical State :
Liquid
Derived From :
Xestospongia sp.
Solubility :
Soluble in DMSO, methanol, and 100% ethanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
14727313
SMILES :
C1CCN2CC[C@H]3C(=C[C@@](CC/C=C/C1)([C@H]4[C@]3(C2)C[C@H]/5N4CCCC/C=C5)O)C6=NC=CC7=C6NC8=CC=CC=C78

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Hamann et al Hamann et al. (PubMed ID 177086550 found that manzamine A decreased tau hyperphosphorylation in human neuroblastoma cells. -SCBT Publication Review
Date published: 2015-05-22
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