Malformin C

Malformin C  (CAS 59926-78-2)

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Synonym: (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]
Application: An inhibitor of bleomycin-induced G2 arrest
CAS Number: 59926-78-2
Molecular Weight: 529.72
Molecular Formula: C23H39N5O5S2
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Inhibitor of bleomycin-induced G2 arrest. Has antibacterial, antimalarial and antitrypanosomal activity. Induces root curvature and malformation in plants and enhances fibrinolytic activity in plants.


Curvatures and Malformations in Bean Plants Caused by Culture Filtrate of Aspergillus niger.: R.W. Curtis ; Plant Physiol. 33, 17 (1958) Abstract; Full Text Root curvatures induced by culture filtrates of Aspergillus niger.: R.W. Curtis ; Science 128, 661 (1958) Abstract Antibiotic properties of malformin.: S. Suda & R.W. Curtis ; Appl. Microbiol. 14, 475 (1966) Abstract; Full Text Enhancement of fibrinolytic activity of U937 cells by malformin A1.: Y. Koizumi & K. Hasumi; J. Antibiot. 55, 78 (2002) Abstract Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells.: K. Hagimori, et al. ; Biol. Pharm. Bull. 30, 1379 (2007) Abstract Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.: Y. Kojima, et al. ; J. Antibiot. 61, 297 (2008) Abstract Solid-phase synthesis and biological activity of malformin C and its derivatives.: Y. Kojima, et al.; J. Antibiot. Epub ahead of print , (2009)

Physical State :
Solubility :
Soluble in 100% ethanol, chloroform, DMSO, and methanol. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
921.28° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
Abrogate the bleomycin (Prod. No. BML-AP302)-induced G2 arrest: IC50 = 0.9 nM (Jurkat cells); Plasmodium falciparum: EC5050 = 163.6 nM
pK Values :
pKa: 12.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :

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Certificate of Analysis

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