Magnolol

Magnolol (CAS 528-43-8)

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Synonym: 5,5'-Diallyl-2,2'-biphenyldiol
Application: An inhibitor of NO and TNF-α production
CAS Number: 528-43-8
Purity: ≥98%
Molecular Weight: 266.3
Molecular Formula: C18H18O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Magnolol is isomeric to honokiol (sc-202653). Magnolol is an anxiolytic, anti-thrombotic and antibacterial. . Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase(iNOS; NOS II) expression (IC50 = 16.8 μM). Magnolol is an activator of CB2 and CB1.


References

Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells: S.E. Yang, et al.; Biochem. Pharmacol. 63, 1641 (2002) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo: X. Bai, et al.; J. Biol. Chem. 278, 35501 (2003) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway: K.S. Ahn, et al.; Mol. Cancer Res. 4, 621 (2006) Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression: B.H. Kim & J.Y. Cho; Acta Pharmacol. Sin. 29, 113 (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals: S. Dikalov, et al.; Biochem. Pharmacol. 76, 589 (2008)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol (1.5 mg/ml), DMSO (53 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (53 mg/ml at 25° C), and DMF (~20 mg/ml).
Storage :
Store at -20° C
Melting Point :
101-102° C
Boiling Point :
~401.0° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
K562: IC50 >18.78 µM (human); HeLa: IC50 >18.78 µM (human); A549: IC50 >18.78 µM (human); HepG2: IC50 = 32 µM (human); HL-60: IC50 = 48 µM (human)
Ki Data :
activate peripheral CB2: Ki= 1.44 µM; activate central CB1: Ki= 3.15 µM
pK Values :
pKa: 9.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DV5105500
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
72300
Merck Index :
14: 5697
MDL Number :
MFCD00016658
SMILES :
C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

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Certificate of Analysis

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What is the physical appearance of this compound?

Asked by: two2igm05
Thank you for your question. Magnolol, sc-204797, is an off-white powder.
Answered by: TechService7
Date published: 2016-12-28
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