M 344 A potent HDAC inhibitor with IC50 of 100 nM

M 344 (CAS 251456-60-7)

M 344 | CAS 251456-60-7 is rated 5.0 out of 5 by 1.
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Application: A potent HDAC inhibitor with IC50 of 100 nM
CAS Number: 251456-60-7
Purity: ≥98%
Molecular Weight: 307.39
Molecular Formula: C16H25N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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M344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.


References

1. Jung, M., et al., 1999. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. Journal of medicinal chemistry. 42(22): 4669-79. PMID: 10579829

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (62 mg/ml at 25° C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25° C), and water (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
239.82° C (Predicted)
Boiling Point :
558.27° C (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
HDAC1: IC50 = 46 nM (human); HDAC: IC50 = 46 nM (rat); Histone deacetylase HD2: IC50 = 100 nM (Maize (Zea mays)); HDAC1: IC50 = 240 nM (rat); HCT-116: IC50 = 200 µM (human)
pK Values :
pKa: 9.48 (Predicted), pKb: 2.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3994
MDL Number :
MFCD03453554
SMILES :
CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

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M 344  Product Citations

See how others have used M 344. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 17230517  Furchert, SE. et al. 2007. Int. J. Cancer. 120: 1787-1794.

PMID: # 16041839  Schäfer, S. et al. 2005. Arch. Pharm. (Weinheim). 338: 347-357.

PMID: # 16262446  Hazzalin, CA. et al. 2005. PLoS Biol. 3: -.

PMID: # 12920038  Cao, H. et al. 2004. Blood. 103: 701-709.

PMID: # 15161353  Zhang, Y. et al. 2004. Radiat. Res. 161: 667-674.

PMID: # 14523559  Kyrylenko, S. et al. 2003. Cell. Mol. Life Sci. 60: 1990-1997.

PMID: # 12817474  Klan, N. et al. 2003. Biol. Chem. 384: 777-785.

PMID: # 19172156  Wang, L. et al. 2009 Mar-Apr. Immunol. Cell Biol. 87: 195-202.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H4 protein expression was observed by WB when comparing M 344 treated NIH/3T3 cells with those that have not been treated. -SCBT QC
Date published: 2015-03-21
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