LY2033298 is an allosteric potentiator that is highly selective for the human M4 mAChR subtype. It has been shown to potentiate acetylcholine binding specifically at the M4 subtype, with no effect on antagonist binding and no effect at hM1/3/5 receptors at any concentration of modulator and a very small allosteric potentiation at the closest homolog, hM2.
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