LY2033298An allosteric potentiator.

LY2033298 (CAS 886047-13-8)

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Application: An allosteric potentiator.
CAS Number: 886047-13-8
Purity: ≥98%
Molecular Weight: 311.79
Molecular Formula: C13H14ClN3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).

LY2033298 is an allosteric potentiator that is highly selective for the human M4 mAChR subtype. It has been shown to potentiate acetylcholine binding specifically at the M4 subtype, with no effect on antagonist binding and no effect at hM1/3/5 receptors at any concentration of modulator and a very small allosteric potentiation at the closest homolog, hM2.


References

1. Chan W.Y., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 10978-10983. PMID: 18678919
2. Nawaratne V., et al. 2008. Mol. Pharmacol. 74: 1119-1131. PMID: 18628403
3. Shirey J.K., et al. 2008. Nat. Chem. Biol. 4: 42-50. PMID: 18059262

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml).
Storage :
Desiccate at -20° C
Boiling Point :
534.7° C at 760 mmHg
Density :
1.48 g/cm3
Refractive Index :
n20D 1.68
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11536903
MDL Number :
MFCD12912423
SMILES :
CC1=C2C(=C(SC2=NC(=C1Cl)OC)C(=O)NC3CC3)N

Download SDS (MSDS)

Certificate of Analysis

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