LY 83583 An inhibitor of guanylate cyclase

LY 83583 (CAS 91300-60-6)

LY 83583 | CAS 91300-60-6 is rated 5.0 out of 5 by 1.
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Synonym: 6-Anilinoquinoline-5,8-quinone
Application: An inhibitor of guanylate cyclase
CAS Number: 91300-60-6
Purity: ≥95%
Molecular Weight: 250.25
Molecular Formula: C15H10N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY 83583 is a quinolinedione that inhibits soluble guanylate cyclase (GCS). Inhibition of GCS has been reported to lower levels of cGMP and cAMP in rat studies. LY 83583 has been shown to inhibit leukotriene synthesis in guinea-pig lung and rat peritoneal cells in vitro, block the release of endothelium-derived relaxing factor, and enhance glucose transporter-1-mediated glucose transport. Kinetic studies have reported that LY 83583 acts as a competitive inhibitor with respect to NADPH (Ki=2.257 μM). LY 83583 is an inhibitor of glutathione reductase.


References

1. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229: 681-689. PMID: 6202867
2. Mυlsch, A., et al. 1988. J. Pharmacol. Exp. Ther. 247: 283-288. PMID: 2902213
3. Klabunde, R.E., et al. 1998. Cardiovasc. Res. 37: 676-683. PMID: 9659451
4. Kumagai, Y., et al. 1998. Eur. J. Pharmacol. 360: 213-218. PMID: 9851588

Physical State :
Solid
Solubility :
Soluble in methanol (11 mg/ml), ethanol (10 mg/ml), 0.1 M HCl (1 mg/ml), methylene chloride, aqueous acid, DMF (~25 mg/ml), DMSO (~25 mg/ml), PBS pH 7.2 (~100 µg/ml), dichloromethane, and 1:175 DMSO:PBS(pH 7.2) (~140 µg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
184-185° C
Boiling Point :
~446.94° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.72
IC50 :
Soluble guanylyl cyclase (sGC): IC50 = 2 µM (human); Leukotriene synthesis: IC50 = 1.8 µM (guinea pig lung and rat peritoneal cells )
Ki Data :
Glutathione reductase: Ki= 3 µM (bovine)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3976
MDL Number :
MFCD00210756
SMILES :
C1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)C=CC=N3

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Certificate of Analysis

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LY 83583  Product Citations

See how others have used LY 83583. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26764200  Wu, P. et al. 2016. American journal of physiology. Renal physiology. ajprenal.00270.2015.

PMID: # 23948706  Ulrich, C. et al. 2013. American journal of physiology. Cell physiology. 305: C803-16.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Li Li, J. et al. (PubMed 24306353) used the guanylate cyclase inhibitor LY 83583, to demonstrate that cGMP and ethylene are involved in maintaining ion homeostasis under salt stress in Arabidopsis roots. -SCBT Publication Review
Date published: 2015-07-11
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