LY 379268A highly selective group II mGlu receptor agonist

LY 379268 (CAS 191471-52-0)

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Synonym: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Application: A highly selective group II mGlu receptor agonist
CAS Number: 191471-52-0
Molecular Weight: 187.15
Molecular Formula: C7H9NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY 379268 has been shown to act as a highly selective group II mGluR agonist with EC50 values of 2.69 and 4.48 nM for mGluR-2 (hmGluR-2) and mGluR-3 (hmGluR-3) respectively. LY 379268 has been shown to display > 80-fold selectivity over group I and group III receptors.

Physical State :
Solid
Solubility :
Soluble in water (20 mM), and 1eq. NaOH (100 mM).
Storage :
Store at 4° C
Melting Point :
291.68° C (Predicted)
Boiling Point :
~413.93° C at 760 mmHg (Predicted)
Density :
~1.72 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
hmGlu2: EC5050 = 2.69 nM; hmGlu3 : EC5050 = 4.48 nM; Glutamate receptor ionotropic, kainate: IC50 = >100 µM (rat); Glutamate receptor ionotropic, AMPA: IC50 = >100 µM (rat)
Ki Data :
mGluR-3: Ki= 5.8 nM (human); mGluR-2: Ki= 14.1 nM (human)
pK Values :
pKa: 1.82 (Predicted), pKb: 8.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RN8985000
PubChem CID :
10197984
SMILES :
C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N

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LY 379268  Product Citations

See how others have used LY 379268. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26071318  Ma, N. et al. 2015. Clin. Immunol. 160: 142-54.

Citations 1 to 1 of 1 total
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