LY-294,002 hydrochloride A highly selective inhibitor of PI 3-kinase

LY-294,002 hydrochloride (CAS 934389-88-5)

LY-294,002 hydrochloride | CAS 934389-88-5 is rated 5.0 out of 5 by 1.
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Synonym: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Application: A highly selective inhibitor of PI 3-kinase
CAS Number: 934389-88-5
Molecular Weight: 343.81
Molecular Formula: C19H17NO3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase (IC50 values are 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively). LY-294,002 hydrochloride induces apoptosis in many cell types by blocking the PI 3-kinase/Akt anti-apoptotic pathway. LY-294,002 hydrochloride is an inhibitor of Pim-1.


References

1. Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241, (1994) 2. Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267, (1996) 3. Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154, 2413-2422, (1995) 4. Chasserot-Golaz et al (1998) Possible involvement of phosphatidyl-3-kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY 294002. J.Neurochem. 70 2347. 5. Ferrandi et al (2007) Phosphoinositide 3-kinase g inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J.Pharmacol. Exp.Ther. 322 923.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM) and Ethanol (5 mM)
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11957589
SMILES :
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl

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LY-294,002 hydrochloride  Product Citations

See how others have used LY-294,002 hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27739443  Lo Cicero, A. et al. 2016. Sci Rep. 6: 34798.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Baranc k Baranc k, M. et al. (PubMed 17010577) reported that LY-294,002, a specific inhibitor of the PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance. -SCBT Publication Review
Date published: 2015-04-15
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