Luteolin An inhibitor of glutathione S-transferase and 15-LO

Luteolin (CAS 491-70-3)

Luteolin | CAS 491-70-3 is rated 5.0 out of 5 by 1.
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Synonym: 3′,4′,5,7-Tetrahydroxyflavone
Application: An inhibitor of glutathione S-transferase and 15-LO
CAS Number: 491-70-3
Purity: ≥98%
Molecular Weight: 286.24
Molecular Formula: C15H10O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP.


References

1. Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16: 43-48. PMID: 8299995
2. Shimoi, L., et al. 1994. Carcinogenesis. 15: 2669-2672. PMID: 7955124
3. Plaumann, B., et al. 1996. Oncogene. 13: 1605-1614. PMID: 8895505
4. Korkina, L.G. and Afanasev, I.B. 1997. Adv. Pharmacol. 38: 151-163. PMID: 8895808

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO, 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml at 25° C), and methanol.
Storage :
Store at 4° C
Melting Point :
330° C (lit.)
Boiling Point :
~616.1° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
soybean and reticulocyte 15-lipoxygenases: IC50 = 0.6 µM; HIV-1(IIIB): IC50 = 16 µM (H9); HIV-1(IIIB): EC5050 = 10 µM (H9); Cyclooxygenase-2: IC50 = 2.5 ug.mL-1 (human); Cytochrome P450 1B1: IC50 = 79 nM (human); Xanthine dehydrogenase: IC50 = 550 nM (human); Dopamine transporter: EC5050 = 1450 nM (rat); H9c2 : EC5050 = 5530 nM (rat)
Ki Data :
Cytochrome P450 1B1: Ki= 56 nM (human); 3-oxoacyl-acyl-carrier protein reductase: Ki= 800 nM (Plasmodium falciparum); Cytochrome P450 1A1: Ki= 890 nM (human); Adenosine A1 receptor: Ki= 1550 nM (rat); Xanthine dehydrogenase: Ki= 1900 nM (Bos taurus)
pK Values :
pKa: 6.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LK9275210
PubChem CID :
5280445
Merck Index :
14: 5614
MDL Number :
MFCD00017309
EC Number :
207-741-0
Beilstein Registry :
292084
SMILES :
C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

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Certificate of Analysis

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Luteolin  Product Citations

See how others have used Luteolin. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28540463  Kalogiouri, NP. et al. 2017. Anal Bioanal Chem. 409: 5413-5426.

PMID: # 28362855  Seo, Y. et al. 2017. PLoS ONE. 12: e0174935.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28071803  Ha, SK. et al. 2017. J. Food Sci. 82: 545-552.

PMID: # 27489195  Sak, K. et al. 2016. Food Funct. 7: 3815-24.

PMID: # 26375549  Lee, N. et al. 2015. Oncotarget. 6: 30130-48.

PMID: # 25542418  Martínez-Fernández, L. et al. 2015. J. Nutr. Biochem. 26: 277-84.

Citations 1 to 7 of 7 total

i have a question "is luteolin soluability in nonpolar solvent? if your answer is yes please which nonpolar solvent?

Asked by: ahmadi
Thank you for your question. Luteolin is soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO (7 mg/ml), 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (~1 mg/ml), water (1 mg/ml) at 25 degrees C, and methanol.
Answered by: Technical Support
Date published: 2018-10-31
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Rated 5 out of 5 by from Shimoi et al Shimoi et al. (PubMed ID 7955124) found that luteolin reduced MNRET frequencies and inhibited lipid peroxidation in mice. -SCBT Publication Review
Date published: 2015-02-16
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