Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP.
1. Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16: 43-48. PMID: 8299995 2. Shimoi, L., et al. 1994. Carcinogenesis. 15: 2669-2672. PMID: 7955124 3. Plaumann, B., et al. 1996. Oncogene. 13: 1605-1614. PMID: 8895505 4. Korkina, L.G. and Afanasev, I.B. 1997. Adv. Pharmacol. 38: 151-163. PMID: 8895808
Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO, 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml at 25° C), and methanol.
i have a question "is luteolin soluability in nonpolar solvent? if your answer is yes please which nonpolar solvent?
Asked by: ahmadi
Thank you for your question. Luteolin is soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO (7 mg/ml), 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (~1 mg/ml), water (1 mg/ml) at 25 degrees C, and methanol.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.