Lumefantrine An antimalarial which inhibits hemozoin formation

Lumefantrine (CAS 82186-77-4)

Lumefantrine | CAS 82186-77-4 is rated 5.0 out of 5 by 1.
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Application: An antimalarial which inhibits hemozoin formation
CAS Number: 82186-77-4
Molecular Weight: 528.94
Molecular Formula: C30H32Cl3NO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lumefantrine is an antimalarial which inhibits hemozoin formation.


References

1. Kumar, N., et al., 1990. Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. Parasitology research. 76(3): 214-8. PMID: 2179946
2. Chotivanich, K., et al., 2000. The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. The Journal of infectious diseases. 182(2): 629-33. PMID: 10915102
3. Mutabingwa, Theonest K., et al., . Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet. 365(9469): 1474-80. PMID: 15850631

Physical State :
Solid
Solubility :
Soluble in methanol, chloroform, DMSO (≥20 mg/ml), and water (slightly).
Storage :
Store at room temperature
Melting Point :
129-132° C
Boiling Point :
~642.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
pK Values :
pKa: 13.44 (Predicted), pKb: 8.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6437380
Merck Index :
14: 5597
MDL Number :
MFCD05662268
Beilstein Registry :
8811003
SMILES :
CCCCN(CCCC)CC(O)C1=C2C(=CC(Cl)=C1)\C(=C/C1=CC=C(Cl)C=C1)C1=C2C=CC(Cl)=C1

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Mekonnen et al Mekonnen et al. (PubMed ID 26271736) found that lumefantrine reduced gametocyte carriage Plasmodium falciparum, making it an effective treatment for malaria. -SCBT Publication Review
Date published: 2015-06-12
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