LTA3 (Leukotriene A3 methyl ester) A suicide inhibitor of LTA4 hydrolase

LTA3 (Leukotriene A3 methyl ester) (CAS 83851-38-1)

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Application: A suicide inhibitor of LTA4 hydrolase
CAS Number: 83851-38-1
Molecular Weight: 334.5
Molecular Formula: C21H34O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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LTA3 (Leukotriene A3 methyl ester) is a member of the leukotrienes which are potent, arachidonic acid-derived eicosanoid lipid mediators. Leukotrienes have demonstrated to play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes primarily act through specific G protein-coupled receptors. LTA3 is an analogue of LTA4 that lacks a C14-C15 double bond. The compound has been observed as a potent suicide inhibitor of LTA4H (LTA4 hydrolase). It has been synthesized from Mead acid (sc-200772) via 5-lipoxygenase. The compound has also been observed to be inhibit rat and human neutrophil LTA4H (LTA4 hydrolases).


References

1. Evans, J.F., et al. 1985. J. Biol. Chem. 260: 10966-10970. PMID: 2993297
2. Orning, L., et al. 1990. J. Biol. Chem. 265: 1491-14916. PMID: 2168394
3. Jakschik, B.A., et al. 1983. J. Biol. Chem. 258: 12797-12800
4. Funk, C.D. 2001. Science. 294: 1871–1875. PMID: 11729303

Formulation :
50 µg/ml in hexane containing 2% triethylamine
Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in water (1 mg/ml), Ethanol, DMF, DMSO, PBS pH 7.2, and chloroform.
Storage :
Store at -80° C
Boiling Point :
68-70°C at 760 mmHg
Refractive Index :
n20D 1.52
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
16219566
MDL Number :
MFCD00065894
SMILES :
CCCCCCCC=CC=CC=CC1C(O1)CCCC(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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