LPD-12 is a water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 μM and [protein] ~ 22 μM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.
1. McGregor, Clare-Louise., et al., 2003. Lipopeptide detergents designed for the structural study of membrane proteins. Nature biotechnology. 21(2): 171-6. PMID: 12524549
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