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Lotaustralin is a cyanogenic glucoside found in trace amounts in a wide variety of plants. Lotaustralin is the glucoside of methyl ethyl ketone cyanohydrin and is structurally related to linamarin, an acetone cyanohydrin glucoside also found in plants. Both lotaustralin and linamarin may be hydrolyzed by the enzyme linamarase to form glucose and a precursor to the toxic compound hydrogen cyanide.
1. Yoshikawa, M., et al., 1997. Bioactive constituents of Chinese natural medicines. IV. Rhodiolae radix. (2).: On the histamine release inhibitors from the underground part of Rhodiola sacra (Prain ex Hamet) S. H. Fu (Crassulaceae): chemical structures of rhodiocyanoside D and sacranosides A and B. Chemical & pharmaceutical bulletin. 45(9): 1498-503. PMID: 9332002
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