Lomefloxacin, Hydrochloride A Topo II antagonist

Lomefloxacin, Hydrochloride (CAS 98079-52-8)

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Synonym: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Application: A Topo II antagonist
CAS Number: 98079-52-8
Molecular Weight: 387.81
Molecular Formula: C17H19F2N3O3 · HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lomefloxacin, Hydrochloride is a fluorinated antibacterial quinolone that acts as a Topo II (DNA gyrase) antagonist.


References

1. Hirose, T., et al., 1987. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrobial agents and chemotherapy. 31(6): 854-9. PMID: 3476021

Physical State :
Solid
Solubility :
Soluble in 1 M NaOH (50 mg/ml), methanol (sparingly), and water (sparingly). Insoluble in 100% ethanol.
Storage :
Store at -20° C
Melting Point :
290-300° C
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Mycobacterium smegmatis: IC50 = 1.44 µM; Plasmodium falciparum: IC50 = 6.31 µM; Trypanosoma brucei brucei: IC50 = 197 µM; HeLa: IC50 = 410 µM (human); HERG: IC50 = 2.40 mM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VB1997500
PubChem CID :
68624
Merck Index :
14: 5562
MDL Number :
MFCD00214312
SMILES :
CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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