Lithium Chloride For assays to study cell-fate, neurobiology and antiviral properties; noted to inhibit GSK-3β

Lithium Chloride (CAS 7447-41-8)

Lithium Chloride | CAS 7447-41-8 is rated 5.0 out of 5 by 2.
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Synonym: LiCl
Application: For assays to study cell-fate, neurobiology and antiviral properties; noted to inhibit GSK-3β
CAS Number: 7447-41-8
Purity: ≥99%
Molecular Weight: 42.39
Molecular Formula: LiCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lithium Chloride is an antiviral metal halide utilized in a variety of assays to study cell-fate and neurobiology. In developing Xenopus embryos, lithium chloride is observed to exert inhibition of GSK-3β (glycogen synthase kinase-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for lithium chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that lithium chloride enhanced the production of inositol triphosphate. The antiviral properties of lithium chloride were noted in a study which showed that the compound inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, lithium chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, lithium chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.


References

1. Klein, P.S., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 8455-8459. PMID: 8710892
2. Chrétien, L., et al. 1997. Cell. Signal. 9: 379-382. PMID: 9376218
3. Adler, J.T., et al. 2009. Ann. Surg. Oncol. 16: 481-486. PMID: 19030935
4. Zhuang, J., et al. 2009. Biochem. Biophys. Res. Commun. 380: 650-654. PMID: 19285016
5. Kasuya, J., et al. 2009. Neurosci. Res. 64: 413-420. PMID: 19410610
6. Sui, X., et al. 2010. Antiviral Res. 85: 346-353. PMID: 19879899

Usage :
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml), alcohol, ether, pyridine, nitrobenzene, acetone, and amyl alcohol.
Storage :
Store at room temperature
Melting Point :
605° C (lit.)
Boiling Point :
1360° C
Density :
2.07 g/cm3 at 20° C
Ki Data :
GSK-3β: Ki= 2 mM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
OJ5950000
PubChem CID :
433294
Merck Index :
14: 5528
MDL Number :
MFCD00011078
EC Number :
231-212-3
SMILES :
[Li+].[Cl-]

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Lithium Chloride  Product Citations

See how others have used Lithium Chloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25992601  Legastelois, R. et al. 2015. PLoS ONE. 10: e0127408.

PMID: # 26544793  Lapp, T. et al. 2015. Investigative ophthalmology & visual science. 56: 7250-9.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from We use this in cell culture studies and get We use this in cell culture studies and get good results.
Date published: 2015-10-23
Rated 5 out of 5 by from Various applications cite the use of Lithium Various applications cite the use of Lithium Chloride in a variety of assays to study cell-fate, neurobiology and anti-viral properties. Noted to inhibit glycogen synthase kinase-3 . -SCBT Publication Review
Date published: 2015-04-21
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