Linomide An immunomodulator and apoptosis inhibitor

Linomide (CAS 84088-42-6)

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Synonym: 1,2-Dihydro-4-hydroxy-N,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
Application: An immunomodulator and apoptosis inhibitor
CAS Number: 84088-42-6
Molecular Weight: 308.33
Molecular Formula: C18H16N2O3
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Linomide is an immunomodulator with antitumour properties. Inhibits apoptosis of T-cells.


References

Ichikawa et al (1992) The antitumor effects of the quinoline-3-carboxamide linomide on Dunning R-3327 rat prostatic cancers. Cancer Res. 52 3022. Vukanovic et al (1993) Antiangiogenic effects of the quinoline-3-carboxamide linomide. Cancer Res. 53 1833. Gonzalo et al (1994) Linomide inhibits programmed cell death of peripheral T cells in vivo. Eur.J.Immunol. 24 48.

Physical State :
Solid
Solubility :
Soluble to 100 mM in 1.1eq. NaOH
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
55197
SMILES :
CN1C2=CC=CC=C2C(=O)C(=C1O)C(=O)N(C)C3=CC=CC=C3

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Certificate of Analysis

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