Lincomycin (U-10149A) is a lincosamide antibiotic isolated from Streptomyces lincolnensis which is reported to inhibit bacterial protein synthesis and is concentration dependent. Sensitive organisms to Lincomycin are usually gram-positive cocci and many anaerobic bacteria. As an inhibitor of protein synthesis, Lincomycin binds to the 50s ribosomal subunit and is reported to inhibit peptidyltransferase and therefore affecting the process of peptide chain initiation. Additionally reported to possibly stimulate the dissociation of peptidyl-tRNA from ribosomes, therefore inhibiting protein synthesis.
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