Lignoceric Acid A 24-carbon saturated fatty acid created as a byproduct of lignan production

Lignoceric Acid (CAS 557-59-5)

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Synonym: FL 88
Application: A 24-carbon saturated fatty acid created as a byproduct of lignan production
CAS Number: 557-59-5
Molecular Weight: 368.63
Molecular Formula: C24H48O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lignoceric Acid is a 23-carbon saturated (23:0) fatty acid. In mammals, it is found in cerebrosides and is synthesized during brain development. The deficient peroxisomal oxidation of very-long-chain fatty acids, including lignoceric acid, contributes to certain syndromes, including Zellweger cerebro-hepato-renal syndrome and X chromosome-linked adrenoleukodystrophy. Lignoceric acid is also a product of lignin production.


References

1. Bourre, J M., et al., 1977. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). European journal of biochemistry / FEBS. 72(1): 41-7. PMID: 836393
2. Singh, I., et al., 1984. Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy. Proceedings of the National Academy of Sciences of the United States of America. 81(13): 4203-7. PMID: 6588384

Physical State :
Solid
Solubility :
Soluble in chloroform (50 mg/ml), THF (~2 mg/ml), and water. Insoluble in ethanol.
Storage :
Store at -20° C
Melting Point :
84-86° C
Boiling Point :
272° C at 10 mmHg
Density :
~0.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.46 (Predicted)
pK Values :
pKa: 4.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11197
Merck Index :
14: 5488
MDL Number :
MFCD00002810
EC Number :
209-180-7
Beilstein Registry :
1728237
SMILES :
CCCCCCCCCCCCCCCCCCCCCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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