Levofloxacin hydrochloride is the hydrochloride salt of Levofloxacin (sc-252953), a fluoroquinolone broad spectrum antibiotic with activity against gram-positive and negative bacteria. Levofloxacin is the active S-(-) isomer of the antibacterial agent ofloxacin (sc-219475) and is significantly more efficacious against bacteria than the R-(+) isomer. Levofloxacin and related fluoroquinolones function by inhibiting Topo II (DNA gyrase) and topoisomerase IV activity and interrupting DNA replication.
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Hurst et alHurst et al. (PubMed ID 12269858) showed that the antibiotic, Levofloxacin hydrochloride, efficiently treated a range of infections and displayed a high tolerability in patients. -SCBT Publication Review
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