Levofloxacin hydrochloride A fluoroquinolone antibiotic inhibitor of DNA gyrase and topoisomerase IV

Levofloxacin hydrochloride (CAS 177325-13-2)

Levofloxacin hydrochloride | CAS 177325-13-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_18, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202693, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 115ms
  • REVIEWS, PRODUCT
Synonym: S-(-)-Ofloxacin hydrochloride
Application: A fluoroquinolone antibiotic inhibitor of DNA gyrase and topoisomerase IV
CAS Number: 177325-13-2
Purity: >89.5%
Molecular Weight: 397.83
Molecular Formula: C18H20FN3O4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Levofloxacin hydrochloride is the hydrochloride salt of Levofloxacin (sc-252953), a fluoroquinolone broad spectrum antibiotic with activity against gram-positive and negative bacteria. Levofloxacin is the active S-(-) isomer of the antibacterial agent ofloxacin (sc-219475) and is significantly more efficacious against bacteria than the R-(+) isomer. Levofloxacin and related fluoroquinolones function by inhibiting Topo II (DNA gyrase) and topoisomerase IV activity and interrupting DNA replication.


References

1. Haffajee, A.D., et al. 1991. J. Periodont. Res. 26: 293-296. PMID: 1831856
2. Davis, R. and Bryson, H.M. 1994. Drugs. 47: 677-700. PMID: 7516863
3. Fish, D.N. and Chow, A.T. 1997. Clin Pharmacokinet. 32: 101-119. PMID: 9068926
4. Drlica, K. and Zhao, X. 1997. Microbiol. Mol. Biol. Rev. 61: 377-392. PMID: 9293187
5. Hurst, M., et al. 2002. Drugs. 62: 2127-2167. PMID: 12269858
6. Schaeffer, A.J. 2003. J. Urol. 170: 337-338. PMID: 14567343

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml).
Storage :
Store at -20° C
Boiling Point :
571.5° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
Optical Activity :
α20/D -104°±4°, c = 1N in chloroform
IC50 :
DNA gyrase subunit A: IC50 = 52 µM (Mycobacterium tuberculosis); MCF7: IC50 = 67 µM (human); Topo IIβ: IC50 = 1 ug/ml (human); DNA topoisomerase 4: IC50 = 2.67 ug/ml (Staphylococcus aureus); Topo II: IC50 = 3.2 ug/ml (human)
Ki Data :
HERG: Ki>150 µM (human); Topo IIβ: Ki= 0.9 ug/ml (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UU8815550
PubChem CID :
9908810
Merck Index :
14: 6771
MDL Number :
MFCD03265511
SMILES :
C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Levofloxacin hydrochloride  Product Citations

See how others have used Levofloxacin hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28272433  Orfi, Z. et al. 2017. Sci Rep. 7: 44073.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 64ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Hurst et al Hurst et al. (PubMed ID 12269858) showed that the antibiotic, Levofloxacin hydrochloride, efficiently treated a range of infections and displayed a high tolerability in patients. -SCBT Publication Review
Date published: 2015-04-28
  • y_2019, m_7, d_18, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202693, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.