Leptomycin B A potent and specific nuclear export inhibitor that acts as an antifungal agent

Leptomycin B (CAS 87081-35-4)

Leptomycin B | CAS 87081-35-4 is rated 4.5 out of 5 by 2.
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Synonym: LMB; Elactocin
Application: A potent and specific nuclear export inhibitor that acts as an antifungal agent
CAS Number: 87081-35-4
Purity: ≥99%
Molecular Weight: 540.74
Molecular Formula: C33H48O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Leptomycin B is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. Leptomycin B alkylates and inhibits CRM1 (exportin), a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.


References

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4. Fukuda, M., et al. 1997. Nature. 390: 308-311. PMID: 9384386
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6. Miska, E.A., et al. 1999. EMBO J. 18: 5099-5107. PMID: 10487761
7. Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 9112-9117. PMID: 10430904
8. Adachi, M., et al. 2000. J. Cell Biol. 148: 849-856. PMID: 10704436
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10. Huang, T.T., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 1014-1019. PMID: 10655476
11. Jang, B.C., et al. 2003. J. Biol. Chem. 278: 2773-2776. PMID: 12468543
12. Fujii, K., et al. 2009. Cell Prolif. 42: 701-709. PMID: 19614672

Appearance :
Film
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Ethanol (preferred) or methanol. Unstable in DMSO
Storage :
Store at -20° C
Boiling Point :
725.79° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6917907
Merck Index :
13: 5463
MDL Number :
MFCD06795848
SMILES :
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C

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Leptomycin B  Product Citations

See how others have used Leptomycin B. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 29061763  Mukherjee, T. et al. 2017. EMBO J. 36: 3501-3516.

PMID: # 26131937  Krönke, J. et al. 2015. Nature. 523: 183-8.

PMID: # 26140478  Sen, B. et al. 2015. Stem cells (Dayton, Ohio). 33: 3065-76.

PMID: # 25852302  Liu, Z. et al. 2015. Cancer cell international. 15: 34.

PMID: # 25321479  Martin-Blanco, NM. et al. 2014. Cell Death Dis. 5: e1472.

PMID: # 25081543  Suico, MA. et al. 2014. The Journal of biological chemistry. 289: 26143-54.

PMID: # 25421715  Ziv, O. et al. 2014. Nature communications. 5: 5437.

PMID: # 21543505  Kalveram, B. et al. 2011. J. Virol. 85: 6234-6243.

PMID: # 21543505  Kalveram, B. et al. 2011. Journal of virology. 85: 6234-43.

PMID: # 21841164  Sakakibara, K. et al. 2011. Blood. 118: 3922-31.

Citations 1 to 10 of 10 total

What form is this product when shipped? (powder, liquid?)

Asked by: chemicalsmg
Thank you for your question. Leptomycin B: sc-358688 is a colorless film.
Answered by: Chemical Support 3
Date published: 2017-03-30

What is the recommended solubility?

Asked by: chemicalsmg
Thank you for your question. Leptomycin B: sc-358688 is freely soluble (10 mg/mL) in most solvents, but long term storage in DMSO or methanol is not recommended.
Answered by: Chemical Support 3
Date published: 2017-03-30

Hi, I need to dilute the 50ug aliquot of Leptomycin B into a 100uM solution. What would be the volume of ethanol to be added?

Asked by: Helena Mello
Thank you for your question. The recommended volume to make a 100 µM solution is 924 µl.
Answered by: Technical Support
Date published: 2017-01-06

what is the retest time?

Asked by: chenlin56
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Rated 5 out of 5 by from Used in cell culture Used in cell culture. Satisfied with product.
Date published: 2015-10-07
Rated 4 out of 5 by from Tachibana Tachibana, et al. (PubMed ID 26296461) treated hSETDB1 overexpressing cell line with leptomycin B, a known nuclear export inhibitor, and proteasome inhibitor MG132. They found that this led to the hSETDB1 protein to accumulate in the nucleus. -SCBT Publication Review
Date published: 2015-04-27
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