Leptomycin B is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. Leptomycin B alkylates and inhibits CRM1 (exportin), a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
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See how others have used Leptomycin B. Click on the entry to view the PubMed entry .
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