Leptomycin A An antifungal antibiotic

Leptomycin A (CAS 87081-36-5)

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Synonym: ATS1287 A, LMA
Application: An antifungal antibiotic
CAS Number: 87081-36-5
Molecular Weight: 526.70
Molecular Formula: C32H46O6
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Leptomycin A is an antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA.


References

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J Antibiot (Tokyo) 36, 639 (1983)

Formulation :
0.1 mg/ml ethanol
Physical State :
Liquid
Derived From :
Streptomyces sp.
Solubility :
Soluble in methanol or 100% ethanol.
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1170, Class 3, Packing group II
PubChem CID :
5384875
MDL Number :
MFCD01711669
SMILES :
CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C

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Certificate of Analysis

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