Latanoprost is a prodrug (isopropyl ester) of 17-phenyl-13,14-dihydro prostaglandin F2α. The free acid form is a potent agonist at PGF2αR (FP receptors). It is in clinical use as a topical antiglaucoma agent and has been shown to reduce IOP (intraoccular pressure) Latanoprost is an activator of EP1 and EP3.
1. Camras, C.B., et al. 1996. Ophthalmology. 103: 1916-1924. PMID: 8942890 2. Kashiwagi, K., et al. 2002. Exp. Eye Res. 74: 41-49. PMID: 11878817
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), acetonitrile, acetone, ethyl acetate, isopropanol, methanol, octanol, and chloroform. Insoluble in water.
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