LatanoprostA prodrug of 17-phenyl-13,14-dihydro prostaglandin F

Latanoprost (CAS 130209-82-4)

Latanoprost | CAS 130209-82-4 is rated 5.0 out of 5 by 1.
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Synonym: Isopropyl (5Z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate;Xalatan
Application: A prodrug of 17-phenyl-13,14-dihydro prostaglandin F
CAS Number: 130209-82-4
Purity: ≥98%
Molecular Weight: 432.59
Molecular Formula: C26H40O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Latanoprost is a prodrug (isopropyl ester) of 17-phenyl-13,14-dihydro prostaglandin F. The free acid form is a potent agonist at PGFR (FP receptors). It is in clinical use as a topical antiglaucoma agent and has been shown to reduce IOP (intraoccular pressure) Latanoprost is an activator of EP1 and EP3.


References

1. Camras, C.B., et al. 1996. Ophthalmology. 103: 1916-1924. PMID: 8942890
2. Kashiwagi, K., et al. 2002. Exp. Eye Res. 74: 41-49. PMID: 11878817

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), acetonitrile, acetone, ethyl acetate, isopropanol, methanol, octanol, and chloroform. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
~583.8° C at 760 mmHg (Predicted)
Density :
~1.1 g/mL (Predicted)
Refractive Index :
n20D 1.54
IC50 :
Prostaglandin F2-alpha receptor: EC5050 = 31.7 nM (Mus musculus)
Ki Data :
Prostanoid FP receptor: Ki= 98 nM (Bos taurus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MJ9669550
PubChem CID :
5311221
Merck Index :
14: 5376
MDL Number :
MFCD00216074
SMILES :
CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Latanoprost  Product Citations

See how others have used Latanoprost. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 11878817  Kashiwagi, K. et al. 2002. Exp. Eye Res. 74: 41-49.

PMID: # 8942890  Camras, CB. et al. 1996. Ophthalmology. 103: 1916-1924.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Camras et al Camras et al. (PubMed ID 8942890) found that latanoprost effectively reduced elevated intraocular pressure in glaucoma patients. -SCBT Publication Review
Date published: 2015-02-16
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