Lasalocid sodiumA polyether ionophore with potent antibacterial activity

Lasalocid sodium (CAS 25999-20-6)

Lasalocid sodium | CAS 25999-20-6 is rated 5.0 out of 5 by 1.
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Synonym: Avatec; Bovatec; Lasalocid A
Application: A polyether ionophore with potent antibacterial activity
CAS Number: 25999-20-6
Purity: ≥95%
Molecular Weight: 612.77
Molecular Formula: C34H53O8•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lasalocid sodium is a polyether ionophore with potent antibacterial activity. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMSO, and DMF. Limited water solubility.
Storage :
Store at -20° C
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
Vero : IC50 = 8.3 µM (Chlorocebus aethiops); Short transient receptor potential channel 4: EC5050 = 5.96 µM (Mus musculus); Neurotensin receptor 1: EC5050 = 30.5 µM (human)
pK Values :
pKa: 3.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GP4180000
PubChem CID :
6426773
MDL Number :
MFCD00078065
EC Number :
200-835-2
SMILES :
CC[C@H]([C@@H]1[C@H](C[C@@](O1)(CC)[C@H]2CC[C@@]([C@@H](O2)C)(CC)O)C)C(=O)[C@@H](C)[C@H]([C@H](C)CCC3=C(C(=C(C=C3)C)O)C(=O)[O-])O.[Na+]

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Certificate of Analysis

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Lasalocid sodium  Product Citations

See how others have used Lasalocid sodium. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28690193  Robertson, AS. et al. 2017. Eur. J. Pharmacol. 812: 104-112.

PMID: # 23615398  Yoon, MJ. et al. 2013. Carcinogenesis. 34: 1918-28.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Bento Bento, CB. et al. (PubMed 25888186) found that hyper-ammonia-producing bacteria in animals fed tropical diets or supplemented with rumen-degradable proteins were sensitive to lasalocid, a polyether ionophore with potent antibacterial activity. -SCBT Publication Review
Date published: 2015-01-06
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