Lasalocid sodium is a polyether ionophore with potent antibacterial activity. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.
Soluble in ethanol, methanol, DMSO, and DMF. Limited water solubility.
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BentoBento, CB. et al. (PubMed 25888186) found that hyper-ammonia-producing bacteria in animals fed tropical diets or supplemented with rumen-degradable proteins were sensitive to lasalocid, a polyether ionophore with potent antibacterial activity. -SCBT Publication Review
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