L-NIO dihydrochlorideA potent inhibitor of NOS1, NOS2, and NOS3

L-NIO dihydrochloride (CAS 36889-13-1)

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Synonym: N5-(1-iminoethyl)-L-ornithine, dihydrochloride
Application: A potent inhibitor of NOS1, NOS2, and NOS3
CAS Number: 36889-13-1
Purity: ≥95%
Molecular Weight: 246.10
Molecular Formula: C7H15N3O2.2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-NIO dihydrochloride has been shown to be a potent inhibitor of NOS3. L-NIO also displays the ability to inhibit NOS1 and NOS2.

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), methanol, and water (100 mM).
Storage :
Desiccate at -20° C
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20/D +19.5°, c = 5.54 in methanol
IC50 :
NOS3: IC50 = 0.5 µM; Acetylcholine-induced relaxation of rat aorta rings: IC50 = 2 µM
Ki Data :
NOS1: Ki= 1.7 µM (rat); NOS3: Ki= 3.9 µM (bovine); NOS2: Ki= 3.9 µM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RM2981970
PubChem CID :
2733507
MDL Number :
MFCD00153817
SMILES :
CC(=NCCC[C@@H](C(=O)O)N)N.Cl.Cl

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Certificate of Analysis

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L-NIO dihydrochloride  Product Citations

See how others have used L-NIO dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27158388  Xu, Z. et al. 2016. Am J Transl Res. 8: 1027-36.

Citations 1 to 1 of 1 total
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