L-Ascorbic acid, free acid (CAS 50-81-7)
Synonym:
Vitamin C
Application:
Also known as vitamin C
CAS Number:
50-81-7
Purity:
≥98%
Molecular Weight:
176.12
Molecular Formula:
C6H8O6
* Refer to Certificate of Analysis for lot specific data (including water content).
L-Ascorbic Acid, Free Acid protects cells against the damaging effects of radiation and oxygen radicals. L-Ascorbic Acid increases the rate of mineralization in osteoblasts, is involved in hydroxylation of proline and lysine, reduces Na+/Ca2+ exchange in cultured astrocytes and modulates cyclic nucleotide levels in B and T cells inhibits apoptosis in cultured rat ovarian follicles. Shown to inhibit T-type Ca++ CP α 1H.
Physical State
:
Solid
Solubility
:
Soluble in water (333 g/l) at 20° C, methanol, and DMSO.
Storage
:
Store at room temperature
Melting Point
:
191° C (dec.)
Boiling Point
:
~415.83° C at 760 mmHg (Predicted)
Density
:
1.65 g/cm3
Refractive Index
:
n20D 1.71 (Predicted)
Optical Activity
:
α20/D +20.5°±21.5°, c = 10 in water
IC50
:
Cav3.2 channels: IC50 = 6.5 µM (HEK 293 cells)
pK Values
:
pKa: 4.5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS
:
CI7650000
PubChem CID
:
54670067
Merck Index
:
14: 830
MDL Number
:
MFCD00064328
EC Number
:
200-066-2
Beilstein Registry
:
84272
SMILES
:
C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
Download SDS (MSDS)
Certificate of Analysis
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Rated 5 out of
5
by
TO from
Kim
Kim, SR. et al. (PubMed 25896849) reported that L-Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals. -SCBT Publication Review
Date published: 2015-03-31
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