L-Ascorbic Acid, Free Acid protects cells against the damaging effects of radiation and oxygen radicals. L-Ascorbic Acid increases the rate of mineralization in osteoblasts, is involved in hydroxylation of proline and lysine, reduces Na+/Ca2+ exchange in cultured astrocytes and modulates cyclic nucleotide levels in B and T cells inhibits apoptosis in cultured rat ovarian follicles. Shown to inhibit T-type Ca++ CP α 1H.
Soluble in water (333 g/l) at 20° C, methanol, and DMSO.
Store at room temperature
191° C (dec.)
~415.83° C at 760 mmHg (Predicted)
n20D 1.71 (Predicted)
α20/D +20.5°±21.5°, c = 10 in water
Cav3.2 channels: IC50 = 6.5 µM (HEK 293 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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L-Ascorbic acid, free acid
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KimKim, SR. et al. (PubMed 25896849) reported that L-Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals. -SCBT Publication Review
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