Molecular structure of L-Allylglycine, CAS Number: 16338-48-0
L-Allylglycine (CAS 16338-48-0)
See product citations (3)
Alternate Names:
L-Allylglycine is also known as 2S-amino-4-pentenoic acid.
Application:
L-Allylglycine is a glutamic acid decarboxylase inhibitor that can induce convulsions and decrease GABA concentration in mice.
CAS Number:
16338-48-0
Purity:
≥97%
Molecular Weight:
115.13
Molecular Formula:
C5H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Allylglycine is an amino acid derivative, As a Glutamic Acid Decarboxylase inhibitor, L-Allylglycine can reduce GAD activity by up to 60% when administered at a dose of 39.8 µmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine can induce convulsions in mice, and decrease GABA concentration throughout their cerebellum, pons, medulla, striatum, cortex, and hippocampus. Chronic administration of L-Allylglycine increased locomotor activity in rats while impairing attention. At high concentrations, L-Allylglycine was found to inhibit GAD in vitro.
L-Allylglycine (CAS 16338-48-0) References
- Allylglycine-induced seizures in male and female rats. | Thomas, J. and Yang, YC. 1991. Physiol Behav. 49: 1181-3. PMID: 1654571
- L-allylglycine dissociates the neural substrates of fear in the periaqueductal gray of rats. | Cunha, JM., et al. 2010. Brain Res Bull. 81: 416-23. PMID: 19800953
- In vivo neurochemical evidence that newly synthesised GABA activates GABA(B), but not GABA(A), receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats. | Saigusa, T., et al. 2012. Neuropharmacology. 62: 907-13. PMID: 21964521
- Stimuli-responsivity of secondary structures of glycopolypeptides derived from poly(L-glutamate-co-allylglycine). | Krannig, KS., et al. 2014. Biomacromolecules. 15: 978-84. PMID: 24491152
- Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate. | Meldrum, BS., et al. 1987. Neuroscience. 22: 17-27. PMID: 2888043
- Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate. | Abshire, VM., et al. 1988. Neuropharmacology. 27: 1171-7. PMID: 3205383
- A human protein hydroxylase that accepts D-residues. | Choi, H., et al. 2020. Commun Chem. 3: 52. PMID: 36703414
- Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats. | Sugimoto, T., et al. 1985. Brain Res. 341: 393-8. PMID: 4041802
- Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. | Chapman, AG., et al. 1984. J Neurochem. 43: 62-70. PMID: 6144732
- Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline or L-allylglycine. | Griffiths, T., et al. 1983. Neuroscience. 10: 385-95. PMID: 6633867
- Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine. | Horton, RW., et al. 1978. J Neurochem. 30: 1501-4. PMID: 670990
- Early changes in the rat hippocampus following seizures induced by bicuculline or L-allylglycine: a light and electron microscope study. | Evans, M., et al. 1983. Neuropathol Appl Neurobiol. 9: 39-52. PMID: 6843775
- In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis. | Bottlaender, M., et al. 1997. Eur J Pharmacol. 321: 13-7. PMID: 9083780
Inhibitor of:
GAD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Allylglycine, 1 g | sc-255236 | 1 g | $72.00 | |||
L-Allylglycine, 5 g | sc-255236A | 5 g | $240.00 | |||
L-Allylglycine, 10 g | sc-255236B | 10 g | $393.00 | |||
L-Allylglycine, 25 g | sc-255236C | 25 g | $770.00 | |||
L-Allylglycine, 100 g | sc-255236D | 100 g | $2030.00 |