L-759633A high affinity and selective CB2 receptor agonist

L-759633 (CAS 174627-50-0)

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Application: A high affinity and selective CB2 receptor agonist
CAS Number: 174627-50-0
Molecular Weight: 384.59
Molecular Formula: C26H40O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-759633 is a high affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). This compound potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).


References

1. Ross, R.A., et al. 1999. Br. J. Pharmacol. 126: 665-672. PMID: 10188977
2. Huffman, J.W., et al. 1999. Bioorg. Med. Chem. 7: 2905-2914. PMID: 10658595
3. Huffman, J.W. 2000. Curr. Pharm. Des. 6: 1323-1337. PMID: 10903395

Formulation :
A solution of Methyl Acetate
Physical State :
Liquid
Solubility :
Soluble to 25 mM in DMSO and to 50 mM in Ethanol
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5311215
SMILES :
CCCCCCC(C)(C)C1=CC2=C(C3CC(=C)CCC3C(O2)(C)C)C(=C1)OC

Download SDS (MSDS)

Certificate of Analysis

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