L-692,585A non-peptidyl GHS R1 acticvator

L-692,585 (CAS 145455-35-2)

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Application: A non-peptidyl GHS R1 acticvator
CAS Number: 145455-35-2
Purity: ≥99%
Molecular Weight: 567.69 (anhydrous)
Molecular Formula: C32H37N7O3•xH2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-692,585 is a potent, non-peptidyl growth hormone receptor (GHS-R1a) agonist with a Ki value of 0.8 nM. L-692,585 increases the plasma growth hormone levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.


References

1. Jacks, T., et al. 1994. J. Endocrinol. 143: 399-406.
2. Smith, R.G., et al. 1997. Endocr. Rev. 18: 621-645.
3. Glavaski-Joksimovic, A., et al. 2002. J. Endocrinol. 175: 625-636.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Desiccate at -20° C
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Rattus norvegicus: EC5050 = 3 nM; Growth hormone-releasing hormone receptor: EC5050 = 3 nM (rat)
Ki Data :
GHS-R1a: Ki= 0.8 nM
pK Values :
pKa: 4.23 (Predicted), pKb: 8.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9872740
SMILES :
C[C@H](CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)O

Download SDS (MSDS)

Certificate of Analysis

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