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KT5823 is a derivative of K-252a (sc-200517) and a selective inhibitor of cGMP-dependent protein kinases (cGKI, Ki=2.4nM) in vitro, but does not inhibit cGMP-dependent protein kinase phosphorylation of VASP in either intact platelets or rat mesangial cells. KT5823 has also been shown to dose-dependently inhibit spontaneous apoptosis of neutrophils, thus suggesting cGK as a mediator of neutrophil spontaneous apoptosis.
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See how others have used KT5823. Click on the entry to view the PubMed entry .
PMID: # 28245258
Asensio-López, MC. et al. 2017. Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes. PLoS ONE. 12: e0172803.
PMID: # 27148059
Pinto, I. et al. 2016. The Role of cGMP on Adenosine A 1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus. Frontiers in pharmacology. 7: 103.
PMID: # 25963768
Nethi, SK. et al. 2015. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 7: 9760-70.
PMID: # 25249574
Roberts, LD. et al. 2015. Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Diabetes. 64: 471-84.
PMID: # 23174781
Zhou, L. et al. 2013. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology (Baltimore, Md.). 57: 1384-93.
PMID: # 18406400
Wang, J. et al. 2008. Involvement of the nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway in the antihyperalgesic effects of bovine lactoferrin in a model of neuropathic pain. Brain research. 1209: 1-7.
PMID: # 18218984
Kunieda, T. et al. 2008. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ. Res.. 102: 607-614.
PMID: # 17568572
Selemidis, S. et al. 2007. Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells. Cardiovasc. Res.. 75: 349-358.
PMID: # 17513385
Yeh, W.L. et al. 2007. Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression Mol Pharmacol. . 72: 440-449.
PMID: # 16242122
Chae, H.J. et al. 2006. Carbon monoxide and nitric oxide protect against tumor necrosis factor-alpha-induced apoptosis in osteoblasts: HO-1 is necessary to mediate the protection Clin. Chim. Acta.. 365: 270-278.
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