KT5823 is a derivative of K-252a (sc-200517) and a selective inhibitor of cGMP-dependent protein kinases (cGKI, Ki=2.4nM) in vitro, but does not inhibit cGMP-dependent protein kinase phosphorylation of VASP in either intact platelets or rat mesangial cells. KT5823 has also been shown to dose-dependently inhibit spontaneous apoptosis of neutrophils, thus suggesting cGK as a mediator of neutrophil spontaneous apoptosis.
1. Hidaka, H., et al. 1984. Biochemistry. 23: 5036-5041. PMID: 6238627 2. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142: 436-440. PMID: 3028414 3. Burkhardt, M., et al. 2000. J. Biol. Chem. 275: 33536-33541. PMID: 10922374 4. Brunetti, M., et al. 2002. Biochem. Biophys. Res. Commun. 297: 498-501. PMID: 12270121
Soluble in water (partly miscible), DMSO (20 mg/ml), DMF (20 mg/ml), and ethyl acetate (5 mg/ml).
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
ZhouZhou, et. al. (PubMed ID 23174781) used KT5823, purchased from SCBT, along with other inhibitors to clarify resistan's signal transduction pathway. HepG2 cells were used with a dosage of 50nM. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.