KT5823 A selective inhibitor of cGKI and spontaneous apoptosis

KT5823 (CAS 126643-37-6)

KT5823 | CAS 126643-37-6 is rated 5.0 out of 5 by 1.
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| See product citations (16)
Synonym: KT-5823
Application: A selective inhibitor of cGKI and spontaneous apoptosis
CAS Number: 126643-37-6
Purity: ≥97%
Molecular Weight: 495.5
Molecular Formula: C29H25N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
KT5823 sc-3534 100 µg $143.00

KT5823 is a derivative of K-252a (sc-200517) and a selective inhibitor of cGMP-dependent protein kinases (cGKI, Ki=2.4nM) in vitro, but does not inhibit cGMP-dependent protein kinase phosphorylation of VASP in either intact platelets or rat mesangial cells. KT5823 has also been shown to dose-dependently inhibit spontaneous apoptosis of neutrophils, thus suggesting cGK as a mediator of neutrophil spontaneous apoptosis.


References

1. Hidaka, H., et al. 1984. Biochemistry. 23: 5036-5041. PMID: 6238627
2. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142: 436-440. PMID: 3028414
3. Burkhardt, M., et al. 2000. J. Biol. Chem. 275: 33536-33541. PMID: 10922374
4. Brunetti, M., et al. 2002. Biochem. Biophys. Res. Commun. 297: 498-501. PMID: 12270121

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), DMSO (20 mg/ml), DMF (20 mg/ml), and ethyl acetate (5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~629.2° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
SNP-stimulated PKG activity: IC50 = 60 nM (dispersed smooth muscle cells)
Ki Data :
PKG: Ki= 0.23 µM; PKC: Ki= 4 µM; PKA: Ki> 10 µM; MLCK: Ki>10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3843
MDL Number :
MFCD09878278
SMILES :
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC

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Certificate of Analysis

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KT5823Product Citations

See how others have used KT5823. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 28245258  Asensio-López, MC. et al. 2017. PLoS ONE. 12: e0172803.

PMID: # 27148059  Pinto, I. et al. 2016. Frontiers in pharmacology. 7: 103.

PMID: # 25963768  Nethi, SK. et al. 2015. Nanoscale. 7: 9760-70.

PMID: # 25249574  Roberts, LD. et al. 2015. Diabetes. 64: 471-84.

PMID: # 23174781  Zhou, L. et al. 2013. Hepatology (Baltimore, Md.). 57: 1384-93.

PMID: # 18406400  Wang, J. et al. 2008. Brain Res. 1209: 1-7.

PMID: # 18218984  Kunieda, T. et al. 2008. Circ. Res. 102: 607-614.

PMID: # 17568572  Selemidis, S. et al. 2007. Cardiovasc. Res. 75: 349-358.

PMID: # 17513385  Yeh, W.L. et al. 2007. Mol Pharmacol. 72: 440-449.

PMID: # 16242122  Chae, H.J. et al. 2006. Clin. Chim. Acta. 365: 270-278.

Citations 1 to 10 of 16 total
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Rated 5 out of 5 by from Zhou Zhou, et. al. (PubMed ID 23174781) used KT5823, purchased from SCBT, along with other inhibitors to clarify resistan's signal transduction pathway. HepG2 cells were used with a dosage of 50nM. -SCBT Publication Review
Date published: 2015-05-07
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