KN-93 An effective inhibitor of CaMKII phosphorylating activity

KN-93  (CAS 139298-40-1)

KN-93 | CAS 139298-40-1 is rated 5.0 out of 5 by 1.
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| See product citations (12)
Synonym: N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
Application: An effective inhibitor of CaMKII phosphorylating activity
CAS Number: 139298-40-1
Purity: ≥95%
Molecular Weight: 501.04
Molecular Formula: C26H29ClN2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

KN-93 sc-202199 1 mg $169.00

KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggests that KN-93 modulates the reaction rate of TH by reducing the Ca2+ mediated phosphorylation levels of TH and inhibiting dopamine formation. In rat pancreatic beta cell studies, KN-93 was shown to block insulin release, and in prostrate cancer research, KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.


1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191: 255-261. PMID: 8383489
3. Rasmussen, G., et al. 1995. Biochem. Cell Biol. 73: 201-207. PMID: 7576494
4. Tombes, R.M., et al. 1995. Cell Growth Differ. 6: 1063-1070. PMID: 8519682
5. Rokhlin, O.W., et al. 2010. Cancer Biol. Ther. 9: 224-235. PMID: 20023417

Usage :
• KN-93 should be dissolved in ethanol first and then diluted with the aqueous buffer of choice, for maximum solubility in aqueous buffers.

• Approximately 0.25 mg/ml of KN-93 can be solubilized in a 1:2 solution of ethanol:PBS (pH 7.2) using this method.

• it is not recommended to store aqueous solution more than one day.

• KN-93 is sparingly soluble in aqueous buffers.
Physical State :
Solubility :
Soluble in DMSO (25 mg/ml), water, 1:2 EtOH:PBS(pH 7.2) (~0.25 mg/ml), ethanol (~30 mg/ml), and DMF (~30 mg/ml).
Storage :
Store at -20° C
Boiling Point :
657.60° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63
IC50 :
CaM kinase II: IC50 = 370 nM; histamine-induced aminopyrine uptake: IC50 = 300 nM (parietal cells)
Ki Data :
CaM binding to the kinase II: Ki= 370 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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Certificate of Analysis

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KN-93 Product Citations

See how others have used KN-93. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 27864646
Yan, X. et al. 2017. Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. Lasers Med Sci. 32: 169-180.

PMID: # 27012864
Gu, Y. et al. 2016. Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis. Leukemia.

PMID: # 24863146
Pagani, JH. et al. 2015. Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Mol. Psychiatry. 20: 490-9.

PMID: # 25042347
Diniz, LP. et al. 2014. Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling. Glia. 62: 1917-31.

PMID: # 24993295
Chae, YJ. et al. 2014. Block of Kv4.3 potassium channel by trifluoperazine independent of CaMKII. Neurosci. Lett.. 578: 159-64.

PMID: # 23345405
Seward, ME. et al. 2013. Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. J. Cell. Sci.. 126: 1278-86.

PMID: # 18978352
Flamand, N. et al. 2009. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J. Biol. Chem.. 284: 306-313.

PMID: # 12933808
Gardoni, F. et al. 2003. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J. Biol. Chem.. 278: 44745-44752.

PMID: # 11782425
Arnould, T. et al. 2002. CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation EMBO J. 21(1): 53-63.

PMID: # 11397804
Wheeler, DG. et al. 2001. Depolarization strongly induces human cytomegalovirus major immediate-early promoter/enhancer activity in neurons. J. Biol. Chem.. 276: 31978-31985.

Citations 1 to 10 of 12 total

Should this product be protected from light?

Asked by: chemicalsmg
Thank you for your question. KN-93 (CAS 139298-40-1), should be protected from light during handling and storage.
Answered by: Chemical Support 3
Date published: 2017-03-09

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-202199, is provided as an off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-18
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Rated 5 out of 5 by from Flamand Flamand, et. al. (PubMed ID 18978352) found that KN-93, a Calcium/calmodulin dependent kinase II, can induce the nuclear export of 5-LO. NIH 3T3, HeLa and COS-1 cells were used. -SCBT Publication Review
Date published: 2015-06-25
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