|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggests that KN-93 modulates the reaction rate of TH by reducing the Ca2+ mediated phosphorylation levels of TH and inhibiting dopamine formation. In rat pancreatic beta cell studies, KN-93 was shown to block insulin release, and in prostrate cancer research, KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.
1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191: 255-261. PMID: 8383489
3. Rasmussen, G., et al. 1995. Biochem. Cell Biol. 73: 201-207. PMID: 7576494
4. Tombes, R.M., et al. 1995. Cell Growth Differ. 6: 1063-1070. PMID: 8519682
5. Rokhlin, O.W., et al. 2010. Cancer Biol. Ther. 9: 224-235. PMID: 20023417
See how others have used KN-93. Click on the entry to view the PubMed entry .
PMID: # 27864646
Yan, X. et al. 2017. Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. Lasers Med Sci. 32: 169-180.
PMID: # 27012864
Gu, Y. et al. 2016. Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis. Leukemia.
PMID: # 24863146
Pagani, JH. et al. 2015. Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Mol. Psychiatry. 20: 490-9.
PMID: # 25042347
Diniz, LP. et al. 2014. Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling. Glia. 62: 1917-31.
PMID: # 24993295
Chae, YJ. et al. 2014. Block of Kv4.3 potassium channel by trifluoperazine independent of CaMKII. Neurosci. Lett.. 578: 159-64.
PMID: # 23345405
Seward, ME. et al. 2013. Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. J. Cell. Sci.. 126: 1278-86.
PMID: # 18978352
Flamand, N. et al. 2009. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J. Biol. Chem.. 284: 306-313.
PMID: # 12933808
Gardoni, F. et al. 2003. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J. Biol. Chem.. 278: 44745-44752.
PMID: # 11782425
Arnould, T. et al. 2002. CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation EMBO J. 21(1): 53-63.
PMID: # 11397804
Wheeler, DG. et al. 2001. Depolarization strongly induces human cytomegalovirus major immediate-early promoter/enhancer activity in neurons. J. Biol. Chem.. 276: 31978-31985.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2017 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.