KN-62 A potent and selective inhibitor of CaMKII

KN-62 (CAS 127191-97-3)

KN-62 | CAS 127191-97-3 is rated 4.5 out of 5 by 2.
  • y_2019, m_2, d_20, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3560, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 58ms
  • REVIEWS, PRODUCT
Synonym: 1-[N,O-Bis(5-Isoquinolinesulfonyl)-N-Methyltyrosyl]-4-Phenylpiperazine
Application: A potent and selective inhibitor of CaMKII
CAS Number: 127191-97-3
Purity: ≥95%
Molecular Weight: 721.84
Molecular Formula: C38H35N5O6S2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 μM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 μM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).


References

1. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265: 4315-4320. PMID: 2155222
2. Minami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199: 241-248. PMID: 8123019
3. Wei, J., et al. 1996. J. Biol. Chem. 271: 24231-24235. PMID: 8798667

Usage :
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Physical State :
Solid
Solubility :
Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93 mg/ml), methanol (10 mg/ml), DMSO (12 mg/ml), chloroform (20 mg/ml), ethanol (~1 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF & DMSO (~30 mg/ml).
Storage :
Store at -20° C
Melting Point :
130° C
Boiling Point :
~964.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.69
IC50 :
CaM kinase II : IC50 = 0.9 µM; P2X7 receptor: IC50 = 15 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NX4899725
PubChem CID :
5312126
MDL Number :
MFCD00083180
SMILES :
CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

KN-62  Product Citations

See how others have used KN-62. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 15 total

PMID: # 27965148  Saito, K. et al. 2017. Toxicol In Vitro. 40: 11-25.

PMID: # 28387756  González-Juarbe, N. et al. 2017. Cell Death Differ. 24: 917-928.

PMID: # 26327597  Estruch, M. et al. 2015. Biochimica et biophysica acta. 1851: 1442-9.

PMID: # 23765195  Hurtado-Carneiro, V. et al. 2013. Mol Neurobiol. 48: 904-920.

PMID: # 22311299  Hurtado-Carneiro V. et al. 2012. Mol Neurobiol. 45(2): 348-361.

PMID: # 18577589  Wayman, GA. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 9093-9098.

PMID: # 18596211  Iglesias, R. et al. 2008. Am. J. Physiol., Cell Physiol. 295: C752-C760.

PMID: # 16928957  Orr, AW. et al. 2006. Mol. Biol. Cell. 17: 4686-4697.

PMID: # 12951199  Song, B. et al. 2003. Neurosci. Lett. 349: 183-186.

PMID: # 12124198  Wang, Y. et al. 2002. Am. J. Physiol. Heart Circ. Physiol. 283: H533-H539.

Citations 1 to 10 of 15 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3560, is provided as a white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-18

How long can we store this chemica at -20 degreel?

Asked by: two2igm05
Thank you for your question. In its powder form, you can store it at -20 degrees for 3 years. Once reconstituted (in DMSO, PBS, etc.) it can be stored at -80 Celsius for up to 6 months. Please contact Technical Service if you have further questions regarding this chemical.
Answered by: Tech Service 9
Date published: 2016-12-15
  • y_2019, m_2, d_21, h_21CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_3560, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 89ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from No comment No comment
Date published: 2015-03-31
Rated 5 out of 5 by from Hurtado Hurtado-Carneiro, et. al. (PubMed ID 23765195) utilized KN-62 (purchased from SCBT) in the research as a CaMK inhibitor. -SCBT Publication Review
Date published: 2015-03-31
  • y_2019, m_2, d_20, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3560, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 225ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.