Ketotifen fumarateA histamine H1 antagonist and mast cell growth inhibitor

Ketotifen fumarate (CAS 34580-14-8)

Ketotifen fumarate | CAS 34580-14-8 is rated 5.0 out of 5 by 1.
  • y_2019, m_8, d_23, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201094, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 138ms
  • REVIEWS, PRODUCT
Application: A histamine H1 antagonist and mast cell growth inhibitor
CAS Number: 34580-14-8
Purity: ≥98%
Molecular Weight: 425.5
Molecular Formula: C19H19NOS C4H4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ketotifen fumarate, a Histamine H1 receptor antagonist, has been noted to inhibit histamine release from lymphocytes and monocytes at 0.1-10 μM. Ketotifen has demonstrated inhibiting characteristics against mast cell growth, therefore reducing myofibroblast hyperplasia. This compound has displayed induction capacities in primary necrosis of interleukin-5-treated eosinophils. Ketotifen fumarate is an inhibitor of PDE.


References

1. Mita, H., et al. 1995. Arzneimittelforschung. 45: 36-40. PMID: 7893266
2. Hasala, H., et al. 2005. J Ocul Pharmacol Ther. 21: 318-327. PMID: 16117696
3. Schoch, C. 2005. Ocul. Immunol. Inflamm. 13: 39-44. PMID: 15804768
4. Monument, M.J., et al. 2010. J Bone Joint Surg Am. 92: 1468-1477. PMID: 20516323

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
Storage :
Desiccate at room temperature
Melting Point :
192° C
Boiling Point :
488.9° C at 760 mmHg (Predicted)
IC50 :
ionophore-induced leukotriene generation: IC50 = 80 mM (human leukocytes)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE8260000
PubChem CID :
5282408
Merck Index :
14: 5307
MDL Number :
MFCD00079394
EC Number :
252-100-0
SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Is this in powder form?

Asked by: lulu10
Thank you for your question. Yes, this is provided as a powder.
Answered by: Tech Service
Date published: 2019-03-25
  • y_2019, m_8, d_23, h_3CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201094, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 97ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Anoush Anoush, M. et al. (PubMed 26236660) evaluated the anti-nociceptive and anti-inflammatory effects of Ketotifen fumarate, a histamine H1 antagonist and inhibitor of mast cell growth, in rats. Ketotifen fumarate demonstrated significant analgesic and anti-inflammatory characteristics in both models of chemical pain and acute inflammation in laboratory animals. -SCBT Publication Review
Date published: 2015-07-20
  • y_2019, m_8, d_23, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201094, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 53ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.