Kasugamycin Hydrochloride Monohydrate An aminoglycoside antibiotic that blocks translation initiation

Kasugamycin Hydrochloride Monohydrate (CAS 6980-18-3)

Kasugamycin Hydrochloride Monohydrate | CAS 6980-18-3 is rated 5.0 out of 5 by 1.
  • y_2019, m_2, d_22, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200104, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 82ms
  • REVIEWS, PRODUCT
Synonym: 3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-α-D-arabino-hexopyranosyl]-D-chiro-inositol Hydrochloride Monohydrate
Application: An aminoglycoside antibiotic that blocks translation initiation
CAS Number: 6980-18-3
Purity: ≥84%
Molecular Weight: 433.84
Molecular Formula: C14H25N3O9•HCl•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Kasugamycin is an aminoglycoside antibiotic that potently inhibits both gram-positive and gram-negative bacteria and blocks translation initiation. To a weaker extent, Kasugamycin also inhibits phytopathogenic microbes. Research shows that Kasugamycin can associate with the 30s ribosomal subunit, which results in the indirect inhibition of the P-site tRNA binding, and blocks protein synthesis.


References

1. Umezawa, H., et al. 1965. J. Antibiot. 18: 101-103. PMID: 14326080
2. Chattopadhyay, S., et al. 1999. Biochim. Biophys. Acta. 1429: 293-298. PMID: 9989214
3. Tamamura, T. and Sato, K. 1999. Jpn J Antibiot. 52: 57-67. PMID: 10202688
4. Moll, I., et al. 2002. Biochem. Biophys. Res. Commun. 297: 1021-1026. PMID: 12359258
5. Schluenzen, F., et al. 2006. Nat. Struct. Mol. Biol. 13: 871-878. PMID: 16998488
6. Surkov, S., et al. 2010. FEBS J. 277: 2428-2439. PMID: 20477873

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
pH :
5.41
Storage :
Store at -20° C
Melting Point :
202-230° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57369825
MDL Number :
MFCD00058459
SMILES :
C[C@@H]1[C@H](C[C@@H]([C@H](O1)OC2[C@@H]([C@H](C([C@@H]([C@@H]2O)O)O)O)O)N)N=C(C(=O)O)N.O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Kasugamycin Hydrochloride Monohydrate  Product Citations

See how others have used Kasugamycin Hydrochloride Monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23804760  Guja, KE. et al. 2013. Nucleic Acids Res. 41: 7947-59.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 89ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Alexander A Alexander A.; et. al. (PubMed ID: 6049299 ) demonstrated that Kasugamycin Hydrochloride Monohydrate did not target pseudomonas, as previous articles have claimed. -SCBT Publication Review
Date published: 2015-04-30
  • y_2019, m_2, d_22, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200104, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 40ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.