JNK Inhibitor VIII An inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release

JNK Inhibitor VIII (CAS 894804-07-0)

JNK Inhibitor VIII | CAS 894804-07-0 is rated 5.0 out of 5 by 1.
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Synonym: N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
Application: An inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release
CAS Number: 894804-07-0
Purity: ≥95%
Molecular Weight: 356.37
Molecular Formula: C18H20N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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JNK inhibitor VIII is an inhibitor of c-Jun N-terminal kinases (JNK) that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK without affecting the expression of IL-6, IL-8, or COX-2. JNK activity studies demonstrate that JNK Inhibitor VIII inhibits the phosphorylation of JNKAR1 and response to anisomycin (sc-3524). Additionally, JNK Inhibitor VIII has been noted to reduce TGF-induced JNK activation. JNK Inhibitor VIII is an inhibitor of JNK1, JNK2 and JNK3.


References

1. Ogino, T., et al. 2009. Leuk. Res. 33: 151-158. PMID: 18718660
2. Kluwe, J., et al. 2010. Gastroenterology. 138: 347-359. PMID: 19782079
3. Turpeinen, T., et al. 2010. J. Pharmacol. Exp. Ther. 333: 310-318. PMID: 20089808
4. Fosbrink, M., et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 5459-5464. PMID: 20212108

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
244.11° C (Predicted)
Boiling Point :
~658.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
JNK1: IC50 = 45 nM (human); JNK2: IC50 = 160 nM (human); NB7: IC50 = 2.27 µM (human); LB2241-RCC: IC50 = 6.58 µM (human); NCI-H1299: IC50 = 13.20 µM (human)
Ki Data :
JNK1: Ki= 2 nM (human); JNK2: Ki= 3.98 nM (human); JNK3: Ki= 52 nM (human); Flt-1: Ki>398.11 nM (human); c-Abl: Ki>630.96 nM (human)
pK Values :
pKa: 11.23 (Predicted), pKb: 1.6 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11624601
MDL Number :
MFCD19690908
SMILES :
CCOC1=C(C(=CC(=N1)NC(=O)CC2=C(C=CC(=C2)OC)OC)N)C#N

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JNK Inhibitor VIII  Product Citations

See how others have used JNK Inhibitor VIII. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21660049  Park, JE. et al. 2012. Cell death and differentiation. 19: 153-61.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Fosbrink et al Fosbrink et al. (PubMed ID 20212108) found that JNK Inhibitor VIII blocked the phosphorylation of JNKAR1 induced by anisomycin. -SCBT Publication Review
Date published: 2015-06-15
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