Ivermectin monosaccharide A semi-synthetic potent inhibitor of nematode larval development

Ivermectin monosaccharide (CAS 123997-64-8)

Ivermectin monosaccharide | CAS 123997-64-8 is rated 5.0 out of 5 by 1.
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Application: A semi-synthetic potent inhibitor of nematode larval development
CAS Number: 123997-64-8
Purity: >99%
Molecular Weight: 730.9
Molecular Formula: C41H62O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ivermectin monosaccharide is a semi-synthetic potent inhibitor of nematode larval development that is devoid of paralytic activity. A part of the Avermectin family of 16-membered macrocyclic lactones derived from the actinomycete Streptomyces avermectinius which exhibit extraordinary anthelmintic activity. Exhibits potent inhibitory effects against nematode larval development, but does not exhibit paralytic activity. The monosaccharide form is used as a sensitive probe for the detection of select types of ivermectin resistance.


References

1. Victoria, J., et al. 2001. Pediatr Dermatol. 18: 63-65. PMID: 11207977
2. Brooks, P.A., et al. 2002. J Paediatr Child Health. 38: 401-404. PMID: 12174005
3. Yates, D.M., et al. 2004. Int. J. Parasitol. 34: 1075-1081. PMID: 15313134
4. Dourmishev, A.L., et al. 2005. Int. J. Dermatol. 44: 981-988. PMID: 16409259
5. Iglesias, L.E., et al. 2006. Parasitol. Res. 100: 93-102. PMID: 16821034
6. Strong, M., et al. 2007. Cochrane Database Syst Rev. 18: CD000320. PMID: 17636630
7. Strycharz, J.P., et al. 2008. J. Med. Entomol. 45: 75-81. PMID: 18283945
8. Molinari, G., et al. 2010. Cytogenet Genome Res. 128:37-45. PMID: 20389039

Physical State :
Solid
Derived From :
Streptomyces avermitilis
Solubility :
Soluble in ethanol, methanol, DMF or DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Ivermectin monosaccharide  Product Citations

See how others have used Ivermectin monosaccharide. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 12458832  Sheriff, JC. et al. 2002. Parasitology. 125: 477-484.

PMID: # 8916406  Ihler, CF. et al. 1996. Vet. Parasitol. 65: 117-125.

PMID: # 8550292  Shoop, WL. et al. 1995. Int. J. Parasitol. 25: 923-927.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Sheriff et al Sheriff et al. (PubMed ID 12458832) used the macrocyclic lactone anthelmintic, ivermectin monosaccharide, to inhibit insulin uptake and to test proper nematode pharyngeal pumping development. -SCBT Publication Review
Date published: 2015-01-19
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