Ivachtin A potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3

Ivachtin (CAS 745046-84-8)

Ivachtin | CAS 745046-84-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-[4-Methyl-8-(morpholin-4-ylsulfon yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
Application: A potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3
CAS Number: 745046-84-8
Molecular Weight: 447.47
Molecular Formula: C20H21N3O7S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ivachtin (2-[4-Methyl-8-(morpholin-4-ylsulfon yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate) is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Also called Caspase-3 Inhibitor VII. It has been shown to have 10-100 fold selectivity over other caspases and higher anti-apoptotic activity than Z-VAD-FMK (sc-3067). Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


References

1. Kravchenko, D.V., et al. 2005. J. Med. Chem. 48: 3680-3683. PMID: 15916416
2. Gauster, M. et al. 2010. Cell Death Differ. 17(2): 336-345. PMID: 19798107

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
299.58° C (Predicted)
Boiling Point :
665.03° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
capase-3: IC50 = 23 nM
pK Values :
pKb: 1.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11201705
MDL Number :
MFCD09971108
SMILES :
CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gauster Gauster, M. et al. (PubMed 19798107) used the caspase-3 inhibitor Ivachtin to demonstrate that caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion. -SCBT Publication Review
Date published: 2015-05-23
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