Ivachtin (2-[4-Methyl-8-(morpholin-4-ylsulfon yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate) is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Also called Caspase-3 Inhibitor VII. It has been shown to have 10-100 fold selectivity over other caspases and higher anti-apoptotic activity than Z-VAD-FMK (sc-3067). Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis. For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).
1. Kravchenko, D.V., et al. 2005. J. Med. Chem. 48: 3680-3683. PMID: 15916416 2. Gauster, M. et al. 2010. Cell Death Differ. 17(2): 336-345. PMID: 19798107
Soluble in DMSO (10 mg/ml).
Store at 4° C
299.58° C (Predicted)
665.03° C at 760 mmHg (Predicted)
1.46 g/cm3 (Predicted)
n20D 1.63 (Predicted)
capase-3: IC50 = 23 nM
pKb: 1.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
GausterGauster, M. et al. (PubMed 19798107) used the caspase-3 inhibitor Ivachtin to demonstrate that caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion. -SCBT Publication Review
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