Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.
Bailey EM, Krakovsky DJ, Rybak MJ. Pharmacother. 10:146-53 (1990).
Soluble in ethanol (<1 mg/ml), water (<1 mg/ml), and DMSO (4 mg/mL).
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Cordeiro et alCordeiro et al. (PubMed ID 26362025) used Itraconazole, an antifungal, to reduce biofilm production of Cryptococcus neoformans and Cryptococcus gattii. -SCBT Publication Review
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