Itraconazole

Itraconazole (CAS 84625-61-6)

Itraconazole | CAS 84625-61-6 is rated 5.0 out of 5 by 1.
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Synonym: Oriconazole
Application: A triazole antifungal agent
CAS Number: 84625-61-6
Purity: ≥99%
Molecular Weight: 705.63
Molecular Formula: C35H38Cl2N8O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.


References

Bailey EM, Krakovsky DJ, Rybak MJ. Pharmacother. 10:146-53 (1990).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (<1 mg/ml), water (<1 mg/ml), and DMSO (4 mg/mL).
Storage :
Store at 4° C
Melting Point :
164-166° C
Boiling Point :
849.98° C at 760 mmHg (Predicted)
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Mdr-1: IC50 = 30 nM (human); P-glycoprotein 3: IC50 = 200 nM (mouse); Trichophyton mentagrophytes: IC50 = 370 nM; Kluyveromyces marxianus: IC50 = 400 nM; Trichophyton rubrum: IC50 = 560 nM
pK Values :
pKb: 6.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XZ5481000
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
55283
Merck Index :
14: 5245
MDL Number :
MFCD00870168
EC Number :
617-596-9
Beilstein Registry :
6042047
SMILES :
CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Itraconazole  Product Citations

See how others have used Itraconazole. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28088354  Albulescu, L. et al. 2017. Antiviral Res. 140: 37-44.

PMID: # 26405807  Lee, S. et al. 2015. PLoS ONE. 10: e0138725.

PMID: # 25640182  Strating, JR. et al. 2015. Cell Rep. 10: 600-15.

PMID: # 26658258  Porcu, G. et al. 2015. PLoS ONE. 10: e0144550.

PMID: # 26319366  Noguchi, KK. et al. 2015. Neurobiol. Dis. 83: 35-43.

PMID: # 23922371  Olliver, M. et al. 2013. J. Infect. Dis. 208: 1474-81.

PMID: # 27303747  Dorobantu, CM. et al. mSphere. 1:

Citations 1 to 7 of 7 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-205724, is provided as a white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11
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Rated 5 out of 5 by from Cordeiro et al Cordeiro et al. (PubMed ID 26362025) used Itraconazole, an antifungal, to reduce biofilm production of Cryptococcus neoformans and Cryptococcus gattii. -SCBT Publication Review
Date published: 2015-02-06
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