Isoimperatorin An anti-inflammatory agent

Isoimperatorin (CAS 482-45-1)

Isoimperatorin | CAS 482-45-1 is rated 5.0 out of 5 by 1.
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Application: An anti-inflammatory agent
CAS Number: 482-45-1
Purity: ≥99%
Molecular Weight: 270.28
Molecular Formula: C16H14O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Isoimperatorin is an anti-inflammatory agent, that also has an effect on proliferation, isolated from the dried roots of Angelicae dahuricae. In bone marrow derived mast cells the compound has been observed to inhibit, at an IC50 24 μM and 10.7 μM, COX-1 and COX-2-dependent phases of prostaglandin D2 generation. In the same cells the compound also inhibited the production of leukotriene D4, demonstrating Isoimperatorin's 5-lipoxygenase inhibitory activity. On prostate cancer cell line DU145 Isoimperatorin impaired proliferation with arrest at G1 and induced cell death. The compound also displayed chemopreventive effects against aflatoxin B-1 on H4IIE cells by increasing GSTα activity. In addition, Isoimperatorin at 2 μM completely abolished 3-methylchoranthrene-inducible CYP1A activity.


References

1. Pokharel, Y.R., et al. 2006. Carcinogenesis. 27: 2483-2490. PMID: 16829687
2. Moon, T.C., et al. 2008. Arch. Pharm. Res. 31: 210-215. PMID: 18365692
3. Kang, J., et al. J. App. Pharm. 2005. 13: 185-189.

Physical State :
Solid
Solubility :
Soluble in chloroform, Ethyl Ac, and water (slightly).
Storage :
Store at -20° C
Melting Point :
107-111° C
Boiling Point :
~448.3° C at 760 mmHg
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
COX-2-dependent phases of prostaglandin D2 generation: IC50 = 10.7 µM (bone marrow derived mast cells); Cholinesterase: IC50 = 23.1 µM (Equus caballus); COX-1-dependent phases of prostaglandin D2 generation: IC50 = 24 µM (bone marrow derived mast cells); AChE: IC50 = 69 µM (human); BACE: IC50 = 244.2 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68081
MDL Number :
MFCD00272155
SMILES :
CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Isoimperatorin, sc-218607, is a light yellow crystal.
Answered by: TechService7
Date published: 2017-01-25
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Rated 5 out of 5 by from Moon et al Moon et al. (PubMed ID 18365692) found that isoimperatorin showed anti-inflammatory capabilities resulting from its cyclooxygenase-2 selective/5-lipoxygenase inhibitory activity. -SCBT Publication Review
Date published: 2015-02-22
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