Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Iron Chelator, Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Wang et alWang et al. (PubMed ID 25261367) found that Iron Chelator, Dp44mT blocked hepatocellular carcinoma metastasis through the N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway. -SCBT Publication Review
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