Iron Chelator, Dp44mT A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand

Iron Chelator, Dp44mT (CAS 152095-12-0)

Iron Chelator, Dp44mT | CAS 152095-12-0 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand
CAS Number: 152095-12-0
Purity: ≥95%
Molecular Weight: 285.37
Molecular Formula: C14H15N5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Iron Chelator, Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.


References

Yuan, J., et al. 2004. Blood 104, 1450.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/mL).
Storage :
Store at 4° C
Melting Point :
165.90° C (Predicted)
Boiling Point :
438.37° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
HL-60 : IC50 = 10 nM (human); HCT-116: IC50 = 2 nM (human); antiproliferative properties in SK-N-MC cells: IC50 = ≤ 0.06 µM; antiproliferative properties in SK-Mel-28 cells: IC50 = ≤ 0.06 µM; antiproliferative properties in MCF-7 cells: IC50 = ≤ 0.06 µM; antiproliferative properties in MRC-5: IC50 = > 25 µM
pK Values :
pKa: 10.18 (Predicted), pKb: 1.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10334137
MDL Number :
MFCD20527329
SMILES :
CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 25261367) found that Iron Chelator, Dp44mT blocked hepatocellular carcinoma metastasis through the N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway. -SCBT Publication Review
Date published: 2015-01-14
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