IQ-1 A cell-permeable tetrahydroisoquinolinylidene

IQ-1 (CAS 331001-62-8)

IQ-1 | CAS 331001-62-8 is rated 5.0 out of 5 by 1.
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Synonym: Wnt Pathway Activator III; 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Application: A cell-permeable tetrahydroisoquinolinylidene
CAS Number: 331001-62-8
Purity: >95%
Molecular Weight: 362.42
Molecular Formula: C21H22N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling. Targets the PR72/130 subunit of PP2A. Thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-administration of IQ-1 (4 μg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term murine Embryonic Stem Cells pluripotency in the absence of serum.


References

1. Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 5668-5673. PMID: 17372190

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage :
Store at 4° C
Boiling Point :
591.23° C at 760 mmHg (Predicted)
Density :
1.24 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3429861
MDL Number :
MFCD00354369
SMILES :
CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N

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Certificate of Analysis

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IQ-1  Product Citations

See how others have used IQ-1. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 17372190  Miyabayashi, T. et al. 2007. Proc. Natl. Acad. Sci. USA. 104(13): 5668-5673.

PMID: # 17372190  Miyabayashi, T. et al. 2007. Proc. Natl. Acad. Sci. USA. 104(13): 5668-5673.

PMID: # 6300073  Thelander, L. et al. 1983. J. Biol. Chem. 258: 4063-4066.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Miyabayashi et al Miyabayashi et al. (PubMed ID 17372190) used IQ-1to increase -catenin/CBP-mediated transcription in order to maintain murine pluritpotency of mouse embryonic stem cells. -SCBT Publication Review
Date published: 2015-04-18
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